{"id":2553,"date":"2020-11-10T00:00:00","date_gmt":"2021-03-18T00:41:51","guid":{"rendered":"https:\/\/www.9-design.net\/?p=2553"},"modified":"2021-03-18T08:41:51","modified_gmt":"2021-03-18T00:41:51","slug":"lenvima%ef%bc%88%e4%bb%91%e4%bc%90%e6%9b%bf%e5%b0%bc%ef%bc%89-keytruda%ef%bc%88%e5%b8%95%e5%8d%9a%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%ef%bc%89%e8%81%94%e5%90%88%e6%96%b9%e6%a1%88%e5%af%b9","status":"publish","type":"post","link":"https:\/\/www.9-design.net\/2020\/11\/10\/lenvima%ef%bc%88%e4%bb%91%e4%bc%90%e6%9b%bf%e5%b0%bc%ef%bc%89-keytruda%ef%bc%88%e5%b8%95%e5%8d%9a%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%ef%bc%89%e8%81%94%e5%90%88%e6%96%b9%e6%a1%88%e5%af%b9\/","title":{"rendered":"LENVIMA\u00ae\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09+ 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400;\">LENVIMA + KEYTRUDA\u8054\u5408\u6cbb\u7597\u8fbe\u5230\u4e86\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\uff08PFS\uff09\u4ee5\u53ca\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff08OS\u548cORR\uff09\uff0c\u7814\u7a76\u6570\u636e\u8bc1\u5b9e\u5728\u610f\u5411\u6cbb\u7597\uff08ITT\uff09\u7814\u7a76\u4eba\u7fa4\u4e2d\uff0c\u4e0e\u8212\u5c3c\u66ff\u5c3c\u76f8\u6bd4\uff0c\u8054\u5408\u6cbb\u7597\u65b9\u6848\u4f7f\u60a3\u8005PFS\u3001OS\u548cORR\u8868\u73b0\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\u3002LENVIMA 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LENVIMA\u8054\u5408\u65b9\u6848\u4e0e\u8212\u5c3c\u66ff\u5c3c\u5355\u836f\u65b9\u6848\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u7ed3\u679c\u663e\u793a\uff0cKEYTRUDA + LENVIMA\u8054\u5408\u6cbb\u7597\u4f7f\u60a3\u8005\u7684PFS\u3001OS\u548cORR\u8868\u73b0\u51fa\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\u201d\uff0c\u9ed8\u514b\u7814\u7a76\u5b9e\u9a8c\u5ba4\u80bf\u7624\u5b66\u4e34\u5e8a\u7814\u7a76\u526f\u603b\u88c1Gregory Lubiniecki\u535a\u58eb\u8bf4\uff0c\u201c\u9ed8\u514b\u5c06\u643a\u624b\u536b\u6750\uff0c\u7ee7\u7eed\u63a2\u7d22KEYTRUDA + LENVIMA\u8054\u5408\u7528\u836f\u7684\u6f5c\u529b\uff0c\u7279\u522b\u662f\u5728\u80be\u7ec6\u80de\u764c\u7b49\u9700\u6c42\u5c1a\u672a\u5f97\u5230\u5145\u5206\u6ee1\u8db3\u7684\u9886\u57df\u3002\u201d<\/p>\n<p style=\"font-weight: 400;\">\u00a0\u201cCLEAR\uff08\u7814\u7a76307\uff09\/KEYNOTE-581\u7684\u7ed3\u679c\u8868\u660eKEYTRUDA + LENVIMA\u5177\u6709\u4f5c\u4e3a\u665a\u671fRCC\u4e00\u7ebf\u6cbb\u7597\u7684\u6f5c\u529b\u3002\u8fd9\u4e9b\u6570\u636e\u4e5f\u8bc1\u660eLENVIMA +\u00a0\u4f9d\u7ef4\u83ab\u53f8\uff08\u8be5\u8054\u5408\u65b9\u6848\u5df2\u88abFDA\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u7684\u665a\u671fRCC\u60a3\u8005\uff09\u5177\u6709\u7528\u4f5c\u4e00\u7ebf\u6cbb\u7597\u7684\u6f5c\u529b\uff0c\u201d\u00a0\u536b\u6750\u526f\u603b\u88c1\u517c\u80bf\u7624\u4e1a\u52a1\u7ec4\u9996\u5e2d\u533b\u5b66\u521b\u65b0\u5b98\u548c\u9996\u5e2d\u53d1\u73b0\u5b98Takashi Owa\u535a\u58eb\u8bf4\uff0c\u201c\u8fd9\u4e9b\u53d1\u73b0\u6fc0\u52b1\u7740\u6211\u4eec\u4e0d\u65ad\u6df1\u5165\u4e86\u89e3\u5e76\u89e3\u51b3\u96be\u6cbb\u764c\u75c7\u60a3\u8005\u672a\u6ee1\u8db3\u7684\u9700\u6c42\u201d\u3002<\/p>\n<p style=\"font-weight: 400;\">\u536b\u6750\u548c\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff09\u6b63\u5728\u901a\u8fc7LEAP\uff08\u4ed1\u4f10\u66ff\u5c3c\u548c\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0cLEnvatinib\u00a0And\u00a0Pembrolizumab\uff09\u4e34\u5e8a\u9879\u76ee\u7ee7\u7eed\u7814\u7a76LENVIMA + KEYTRUDA\u8054\u5408\u7528\u836f\u7684\u60c5\u51b5\uff0c\u6d89\u53ca19\u9879\u8bd5\u9a8c\u300113\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\uff0c\u8fd9\u4e9b\u80bf\u7624\u7c7b\u578b\u5305\u62ec\u5b50\u5bab\u5185\u819c\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001RCC\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u80c6\u9053\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u5375\u5de2\u764c\u548c\u4e09\u9634\u6027\u4e73\u817a\u764c\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><strong>\u5173\u4e8eCLEAR\uff08\u7814\u7a76307\uff09\/KEYNOTE-581<\/strong><\/p>\n<p style=\"font-weight: 400;\">CLEAR\uff08\u7814\u7a76307\uff09\/KEYNOTE-581\u662f\u4e00\u9879\u8bc4\u4ef7LENVIMA\u8054\u5408KEYTRUDA\u6216\u4f9d\u7ef4\u83ab\u53f8\u4e0e\u8212\u5c3c\u66ff\u5c3c\u5355\u836f\u76f8\u6bd4\uff0c\u7528\u4e8e\u665a\u671fRCC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6027\u3001III\u671f\u8bd5\u9a8c\uff08ClinicalTrials.gov\uff0c<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02811861\"><u>NCT02811861<\/u><\/a>\uff09\u3002\u672c\u7814\u7a76\u5171\u5165\u7ec4\u7ea61050\u4f8b\u60a3\u8005\uff0c\u968f\u673a\u5206\u4e3a\u4e09\u4e2a\u6cbb\u7597\u7ec4\uff0c\u5206\u522b\u63a5\u53d7LENVIMA\uff0818 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\uff085 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09[A\u7ec4]\uff1b\u6216LENVIMA\uff0820 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400;\">\u636e\u4f30\u8ba1\uff0c2018\u5e74\u5168\u7403\u65b0\u8bca\u65ad\u80be\u764c\u75c5\u4f8b\u8d85\u8fc7403,000\u4f8b\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u8d85\u8fc7175,000\u4f8b<sup>1<\/sup>\u30022018\u5e74\uff0c\u65e5\u672c\u65b0\u53d1\u75c5\u4f8b\u8d85\u8fc724,000\u4f8b\uff0c\u6b7b\u4ea18000\u4f8b<sup>1<\/sup>\u3002\u636e\u4f30\u8ba1\uff0c\u4ec5\u5728\u7f8e\u56fd\uff0c2020\u5e74\u5c06\u6709\u8fd174, 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400;\">\u536b\u6750\u4e13\u6ce8\u4e8e\u6297\u764c\u836f\u7269\u7684\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08\u4ece\u73b0\u6709\u7684\u81ea\u4e3b\u7814\u53d1\u7684\u5316\u5408\u7269\u4e2d\u5f97\u5230\u4e86\u5927\u91cf\u7684\u7ecf\u9a8c\u548c\u77e5\u8bc6\uff09\u4ee5\u53ca\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u53ca\u5f02\u5e38\u526a\u63a5\u7684\u56e0\u7d20\uff08\u5229\u7528RNA\u526a\u5207\u5e73\u53f0\uff09\u7b49\u9886\u57df\uff08<em>Ricchi<\/em>\uff09\u3002\u5728\u8fd9\u4e9b\u9886\u57df\uff0c\u8fd8\u6709\u5f88\u591a\u60a3\u8005\u7684\u9700\u6c42\u672a\u5f97\u5230\u771f\u6b63\u7684\u6ee1\u8db3\uff0c\u536b\u6750\u5e0c\u671b\u6210\u4e3a\u80bf\u7624\u5b66\u9886\u57df\u7684\u9886\u5bfc\u8005\u3002\u536b\u6750\u5e0c\u671b\u4ece\u8fd9\u4e9b<em>Ricchi\u00a0<\/em>\u4e2d\u53d1\u73b0\u5177\u6709\u65b0\u9776\u70b9\u3001\u65b0\u4f5c\u7528\u673a\u5236\u5e76\u6709\u671b\u6cbb\u6108\u764c\u75c7\u7684\u521b\u65b0\u836f\u3002<\/p>\n<p style=\"font-weight: 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style=\"font-weight: 400;\">\u6709\u5173\u536b\u6750\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<u>www.eisai.com<\/u>\uff08\u9002\u7528\u4e8e\u5168\u7403\uff09\u3001<u>us.eisai.com<\/u>\uff08\u9002\u7528\u4e8e\u7f8e\u56fd\uff09\u6216<u>www.eisai.eu<\/u>\uff08\u9002\u7528\u4e8e\u6b27\u6d32\u3001\u4e2d\u4e1c\u3001\u975e\u6d32\uff09\uff0c\u4e5f\u53ef\u901a\u8fc7Twitter\uff08<a href=\"https:\/\/twitter.com\/eisaius\">\u7f8e\u56fd<\/a>\u548c<a href=\"https:\/\/twitter.com\/eisai_sdgs\">\u5168\u7403<\/a>\uff09\u548c<a href=\"https:\/\/www.linkedin.com\/company\/eisai\/\">LinkedIn<\/a>\uff08\u4ec5\u9002\u7528\u4e8e\u7f8e\u56fd\uff09\u4e0e\u6211\u4eec\u8054\u7cfb\u3002<\/p>\n<p style=\"font-weight: 400;\">\u00a0<strong><br \/>\n<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff09\u4e13\u6ce8\u4e8e\u764c\u75c7<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u9ed8\u514b\u96c6\u56e2\u7684\u76ee\u6807\u662f\u5c06\u7a81\u7834\u6027\u79d1\u5b66\u8f6c\u5316\u4e3a\u521b\u65b0\u578b\u80bf\u7624\u836f\u7269\uff0c\u4ee5\u9020\u798f\u5168\u7403\u764c\u75c7\u60a3\u8005\u3002\u5728\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff09\uff0c\u4e3a\u764c\u75c7\u60a3\u8005\u5e26\u6765\u65b0\u5e0c\u671b\u7684\u6f5c\u529b\u63a8\u52a8\u4e86\u516c\u53f8\u7684\u76ee\u6807\uff0c\u652f\u6301\u764c\u75c7\u836f\u7269\u7684\u53ef\u53ca\u6027\u662f\u516c\u53f8\u7684\u627f\u8bfa\u3002\u4f5c\u4e3a\u5173\u6ce8\u764c\u75c7\u7684\u4e00\u90e8\u5206\uff0c\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff09\u81f4\u529b\u4e8e\u63a2\u7d22\u80bf\u7624\u514d\u75ab\u5b66\u7684\u6f5c\u529b\uff0c\u8fd9\u662f\u8be5\u884c\u4e1a\u4e2d\u6700\u5927\u7684\u5f00\u53d1\u9879\u76ee\u4e4b\u4e00\uff0c\u6db5\u76d630\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u3002\u516c\u53f8\u8fd8\u5c06\u7ee7\u7eed\u901a\u8fc7\u6218\u7565\u6027\u6536\u8d2d\u6765\u52a0\u5f3a\u516c\u53f8\u7684\u4ea7\u54c1\u7ec4\u5408\uff0c\u5e76\u4f18\u5148\u5f00\u53d1\u5177\u6709\u6f5c\u529b\u7684\u51e0\u79cd\u6709\u671b\u6539\u5584\u665a\u671f\u764c\u75c7\u6cbb\u7597\u7684\u80bf\u7624\u5019\u9009\u836f\u7269\u3002\u6709\u5173\u516c\u53f8\u80bf\u7624\u5b66\u4e34\u5e8a\u8bd5\u9a8c\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.merck.com\/clinicaltrials\">www.merck.com\/clinicaltrials<\/a>\u3002<\/p>\n<p><span style=\"font-weight: 400;\"><strong>\u00a0<\/strong><\/span><\/p>\n<p style=\"font-weight: 400;\"><strong>\u5173\u4e8e\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff09<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u5728\u8d85\u8fc7125\u5e74\u7684\u65f6\u95f4\u91cc\uff0c\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff0c\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u5883\u5916\u79f0\u4e3aMSD\uff09\u4e00\u76f4\u81f4\u529b\u4e8e\u4e3a\u751f\u547d\u7684\u5ef6\u7eed\u800c\u53d1\u660e\u836f\u7269\uff0c\u4e3a\u4e16\u754c\u4e0a\u5f88\u591a\u6700\u5177\u6311\u6218\u6027\u7684\u75be\u75c5\u63d0\u4f9b\u836f\u7269\u548c\u75ab\u82d7\uff0c\u4ee5\u5b9e\u73b0\u516c\u53f8\u62ef\u6551\u751f\u547d\u548c\u6539\u5584\u751f\u6d3b\u7684\u4f7f\u547d\u3002\u516c\u53f8\u901a\u8fc7\u5f71\u54cd\u6df1\u8fdc\u7684\u653f\u7b56\u3001\u9879\u76ee\u548c\u4f19\u4f34\u5173\u7cfb\u589e\u52a0\u83b7\u5f97\u533b\u7597\u4fdd\u5065\u7684\u673a\u4f1a\uff0c\u4ee5\u793a\u516c\u53f8\u5bf9\u60a3\u8005\u548c\u4eba\u7fa4\u5065\u5eb7\u7684\u627f\u8bfa\u3002\u5982\u4eca\uff0c\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\uff09\u5728\u9884\u9632\u548c\u6cbb\u7597\u5a01\u80c1\u4eba\u7c7b\u548c\u52a8\u7269\u7684\u75be\u75c5\uff08\u5305\u62ec\u764c\u75c7\u3001HIV\u548c\u57c3\u535a\u62c9\u75c5\u6bd2\u7b49\u611f\u67d3\u6027\u75be\u75c5\u4ee5\u53ca\u65b0\u51fa\u73b0\u7684\u52a8\u7269\u75be\u75c5\uff09\u9886\u57df\uff0c\u4e00\u76f4\u4fdd\u6301\u8d70\u5728\u524d\u6cbf\uff0c\u81f4\u529b\u4e8e\u6210\u4e3a\u5168\u7403\u9886\u5148\u7684\u7814\u53d1\u5bc6\u96c6\u578b\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.merck.com\/\">www.merck.com<\/a>\uff0c\u5e76\u901a\u8fc7<a href=\"https:\/\/twitter.com\/Merck\">Twitter<\/a>\u3001<a href=\"https:\/\/www.facebook.com\/MerckInvents\/\">Facebook<\/a>\u3001<a href=\"https:\/\/www.instagram.com\/merck\/\">Instagram<\/a>\u3001<a href=\"https:\/\/www.youtube.com\/user\/Merck\">YouTube<\/a>\u548c<a href=\"https:\/\/www.linkedin.com\/company\/merck\">LinkedIn<\/a>\u4e0e\u516c\u53f8\u8054\u7cfb\u3002<\/p>\n<p style=\"font-weight: 400;\">\u00a0<strong><br \/>\n<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff09\u7684\u524d\u77bb\u6027\u58f0\u660e<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u9ed8\u514b\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\uff0c\u4e0b\u6587\u7b80\u79f0\u201c\u516c\u53f8\u201d\uff09\u7684\u65b0\u95fb\u7a3f\u4e2d\u5305\u542b\u201c\u524d\u77bb\u6027\u58f0\u660e\u201d\uff0c\u8fd9\u4e9b\u58f0\u660e\u662f\u6839\u636e1995\u5e74\u7f8e\u56fd\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u4e2d\u7684\u5b89\u5168\u6e2f\u89c4\u5b9a\u505a\u51fa\u7684\u3002\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u57fa\u4e8e\u516c\u53f8\u7ba1\u7406\u5c42\u76ee\u524d\u7684\u4fe1\u5ff5\u548c\u671f\u671b\uff0c\u5e76\u53d7\u5236\u4e8e\u53ef\u80fd\u51fa\u73b0\u7684\u91cd\u5927\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u56e0\u7d20\u3002\u5bf9\u4e8e\u7ba1\u7ebf\u4ea7\u54c1\uff0c\u65e0\u6cd5\u4fdd\u8bc1\u4ea7\u54c1\u5c06\u83b7\u5f97\u5fc5\u8981\u7684\u76d1\u7ba1\u6279\u51c6\u6216\u8bc1\u660e\u5176\u4f1a\u53d6\u5f97\u5546\u4e1a\u5316\u6210\u529f\u3002\u5982\u679c\u57fa\u672c\u5047\u8bbe\u88ab\u8bc1\u660e\u4e0d\u51c6\u786e\u6216\u5b58\u5728\u98ce\u9669\u6216\u4e0d\u786e\u5b9a\u6027\uff0c\u5219\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6240\u5217\u7ed3\u679c\u5b58\u5728\u91cd\u5927\u5dee\u5f02\u3002<\/p>\n<p style=\"font-weight: 400;\">\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4e00\u822c\u884c\u4e1a\u72b6\u51b5\u548c\u7ade\u4e89\uff1b\u4e00\u822c\u7ecf\u6d4e\u56e0\u7d20\uff0c\u5305\u62ec\u5229\u7387\u548c\u8d27\u5e01\u6c47\u7387\u6ce2\u52a8\uff1b\u5168\u7403\u7206\u53d1\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u75be\u75c5\uff08COVID-19\uff09\u7684\u5f71\u54cd\uff1b\u7f8e\u56fd\u548c\u56fd\u9645\u5236\u836f\u884c\u4e1a\u76d1\u7ba1\u548c\u533b\u7597\u4fdd\u5065\u7acb\u6cd5\u7684\u5f71\u54cd\uff1b\u63a7\u5236\u533b\u7597\u4fdd\u5065\u6210\u672c\u7684\u5168\u7403\u8d8b\u52bf\uff1b\u6280\u672f\u8fdb\u6b65\uff0c\u7ade\u4e89\u8005\u83b7\u5f97\u7684\u65b0\u4ea7\u54c1\u548c\u4e13\u5229\uff1b\u65b0\u4ea7\u54c1\u5f00\u53d1\u56fa\u6709\u7684\u6311\u6218\uff0c\u5305\u62ec\u83b7\u5f97\u76d1\u7ba1\u6279\u51c6\uff1b\u516c\u53f8\u51c6\u786e\u9884\u6d4b\u672a\u6765\u5e02\u573a\u60c5\u51b5\u7684\u80fd\u529b\uff1b\u751f\u4ea7\u56f0\u96be\u6216\u5ef6\u8bef\uff1b\u56fd\u9645\u7ecf\u6d4e\u7684\u91d1\u878d\u4e0d\u7a33\u5b9a\u6027\u548c\u4e3b\u6743\u98ce\u9669\uff1b\u5bf9\u516c\u53f8\u4e13\u5229\u548c\u521b\u65b0\u4ea7\u54c1\u5176\u4ed6\u4fdd\u62a4\u7684\u6709\u6548\u6027\u7684\u4f9d\u8d56\u6027\uff1b\u4ee5\u53ca\u8bc9\u8bbc\u98ce\u9669\uff0c\u5305\u62ec\u4e13\u5229\u8bc9\u8bbc\u548c\/\u6216\u76d1\u7ba1\u884c\u52a8\u3002<\/p>\n<p style=\"font-weight: 400;\">\u516c\u53f8\u65e0\u4e49\u52a1\u516c\u5f00\u66f4\u65b0\u4efb\u4f55\u524d\u77bb\u6027\u58f0\u660e\uff0c\u65e0\u8bba\u8be5\u7b49\u66f4\u65b0\u662f\u57fa\u4e8e\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u9879\uff0c\u6216\u8005\u4efb\u4f55\u5176\u4ed6\u539f\u56e0\u3002\u53ef\u80fd\u5bfc\u81f4\u7ed3\u679c\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u6240\u8ff0\u7ed3\u679c\u6709\u5b9e\u8d28\u6027\u5dee\u5f02\u7684\u5176\u4ed6\u56e0\u7d20\u89c1\u516c\u53f8\u5411\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\uff08SEC\uff09\u63d0\u4ea4\u7684\u516c\u53f82019\u5e74\u5e74\u5ea6\u62a5\u544a10-K\u8868\u683c\u548c\u5176\u4ed6\u7533\u62a5\u6587\u4ef6\uff0c\u53ef\u8bbf\u95eeSEC\u7f51\u7ad9\uff08<a href=\"http:\/\/www.sec.gov\/\">www.sec.gov<\/a>\uff09\u67e5\u9605\u8fd9\u4e9b\u8d44\u6599\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><sup>1<\/sup>\u00a0GLOBOCAN2018\uff1a2012-2018\u5e74\u5168\u7403\u764c\u75c7\u53d1\u75c5\u7387\u3001\u6b7b\u4ea1\u7387\u548c\u60a3\u75c5\u7387\u4f30\u8ba1\u503c\u3002<a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/29-Kidney-fact-sheet.pdfhttp:\/globocan.iarc.fr\/\">https\uff1a\/\/\/gco.iarc.Fr\/today\/data\/factsheets\/cancer\/29-Kidney-fact-sheet.pdfhttp\uff1a\/\/\/globocan.iarc.fr\/.<\/a><\/p>\n<p style=\"font-weight: 400;\"><sup>2<\/sup>\u00a0\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff0c\u76d1\u6d4b\u3001\u6d41\u884c\u75c5\u5b66\u548c\u6700\u7ec8\u7ed3\u679c\u9879\u76ee\uff08SEER\uff09\u201c\u764c\u75c7\u7edf\u8ba1\u8d44\u6599\uff1a\u80be\u53ca\u80be\u76c2\u764c\u201dhttps:\/\/seer.cancer.gov\/statfacts\/html\/kidrp.html.<\/p>\n<p style=\"font-weight: 400;\"><sup>3<\/sup>\u00a0\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff0c\u201c\u6709\u5173\u80be\u764c\u7684\u5173\u952e\u7edf\u8ba1\u6570\u636e\u201d\u00a0<a href=\"https:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-statistics.html\">https:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-<\/a><u>\u00a0<\/u><a href=\"https:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-statistics.html\">statistics.html.<\/a><\/p>\n<p style=\"font-weight: 400;\"><sup>4<\/sup>\u00a0\u300a\u6709\u5173\u80be\u764c\u7684\u5173\u952e\u7edf\u8ba1\u6570\u636e\u300b\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u3002<a href=\"https:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-statistics.html\">https:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-statistics.html.<\/a><\/p>\n<p style=\"font-weight: 400;\"><sup>5<\/sup>\u00a0Thomas A. Z. et al.\u00a0\u8f6c\u79fb\u7624\u5207\u9664\u672f\u5728\u80be\u7ec6\u80de\u764c\u4f34\u8089\u7624\u6837\u5206\u5316\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\uff1a\u5339\u914d\u5bf9\u7167\u5206\u6790\u3002<em>\u7f8e\u56fd\u6ccc\u5c3f\u5916\u79d1\u6742\u5fd7<\/em>\u00a02016\u5e749\u6708\uff1b\u7b2c196(3)\u671f\uff1a \u7b2c678-684\u9875<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5014677\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5014677\/.<\/a><\/p>\n<p style=\"font-weight: 400;\"><sup>6<\/sup>\u00a0Shinder B et al. \u665a\u671f\u548c\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684\u5916\u79d1\u6cbb\u7597\uff1a\u591a\u5b66\u79d1\u65b9\u6cd5\u80bf\u7624\u5b66\u524d\u8a00\u6742\u5fd72017\u5e74\uff1b\u7b2c7\u671f\uff1a\u7b2c107\u9875.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449498\/#%20ffn%20sectitle.\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449498\/# ffn sectitle.<\/a><\/p>\n<p style=\"font-weight: 400;\"><sup>7<\/sup>\u00a0Padala, S. A., Barsouk, A., Thandra, K. C., Saginala, K., Mohammed, A., Vakiti, A., Rawla, P., &amp; Barsouk, A. (2020). \u80be\u7ec6\u80de\u764c\u6d41\u884c\u75c5\u5b66\u3002\u4e16\u754c\u80bf\u7624\u5b66\u6742\u5fd7\uff0c\u7b2c11 (3)\u671f\uff0c\u7b2c79-87\u9875<a href=\"https:\/\/doi.org\/10.14740\/wjon1279\">https:\/\/doi.org\/10.14740\/wjon1279.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ENVIMA\u00ae\u00a0+\u00a0\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u6cbb\u7597\u4e0e\u8212\u5c3c\u66ff\u5c3c\u76f8\u6bd4\uff0c\u4e5f\u53ef\u663e\u8457\u6539\u5584PFS\u548cORR\uff0c\u7ed3\u679c\u6709\u7edf\u8ba1\u5b66\u610f\u4e49<\/p>\n<p>III\u671f\u4e34\u5e8a\u7814\u7a76CLEAR\u8bd5\u9a8c\uff08\u7814\u7a76307\uff09\/KEYNOTE-581\u7684\u7ed3\u679c\u5c06\u5728\u5373\u5c06\u53ec\u5f00\u7684\u533b\u5b66\u4f1a\u8bae\u4e0a\u53d1\u5e03<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"_links":{"self":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/2553"}],"collection":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/comments?post=2553"}],"version-history":[{"count":2,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/2553\/revisions"}],"predecessor-version":[{"id":2555,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/2553\/revisions\/2555"}],"wp:attachment":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/media?parent=2553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/categories?post=2553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/tags?post=2553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<a href="http://www.9-design.net/">久久人人97超碰超国产,天天摸夜夜添夜夜无码,久久精品人人槡人妻人人玩,97碰碰碰人妻无码视频</a>
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