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href=\"http:\/\/www.remapcap.org\/\"><strong><em>www.remapcap.org<\/em><\/strong><\/a><strong><em>\u5e76\u5173\u6ce8<\/em><\/strong><strong><em><u>@remap cap<\/u><\/em><\/strong><\/p>\n<p style=\"font-weight: 400;\">\u00a0<strong><br \/>\n<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>\u5173\u4e8eOtezla<sup>\u00ae<\/sup>\uff08\u963f\u666e\u65af\u7279\uff09<\/strong><\/p>\n<p style=\"font-weight: 400;\">Otezla<sup>\u00ae<\/sup>\uff08\u963f\u666e\u65af\u7279\uff09\u662f\u73af\u78f7\u9178\u817a\u82f7\uff08cAMP\uff09\u7279\u5f02\u6027\u78f7\u9178\u4e8c\u916f\u91764\uff08PDE4\uff09\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3002PDE4\u6291\u5236\u53ef\u5bfc\u81f4\u7ec6\u80de\u5185cAMP\u6c34\u5e73\u5347\u9ad8\uff0c\u56e0\u6b64\u53ef\u95f4\u63a5\u8c03\u8282\u708e\u75c7\u4ecb\u8d28\u7684\u751f\u6210\u3002\u5c1a\u672a\u660e\u786eOtezla\u5728\u60a3\u8005\u4e2d\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\u7684\u5177\u4f53\u673a\u5236\u3002<\/p>\n<p style=\"font-weight: 400;\">Otezla\u53ef\u901a\u8fc7\u6291\u5236PDE4\uff0c\u8c03\u8282\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u5176\u4ed6\u4ecb\u8d28\u7684\u4ea7\u751f\uff0c\u56e0\u6b64\u53ef\u80fd\u6709\u52a9\u4e8e\u6291\u5236COVID-19\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u75c7\u72b6\u3001\u4f53\u5f81\u53ca\u4e0e\u80ba\u90e8\u76f8\u5173\u7684\u708e\u75c7\u53cd\u5e94\u3002\u5b89\u8fdb\u8ba1\u5212\u4e0e\u5e73\u53f0\u8bd5\u9a8c\u5408\u4f5c\uff0c\u7814\u7a76Otezla\u6cbb\u7597COVID-19\u4f4f\u9662\u60a3\u8005\u7684\u6548\u679c\u3002<\/p>\n<p style=\"font-weight: 400;\">\u00a0<strong><br \/>\n<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>Otezla<sup>\u00ae<\/sup><\/strong><strong>\uff08\u963f\u666e\u65af\u7279\uff09\u7f8e\u56fd\u9002\u5e94\u75c7<\/strong><\/p>\n<p>Otezla<sup>\u00ae<\/sup>\uff08\u963f\u666e\u65af\u7279\uff09\u9002\u7528\u4e8e\u6cbb\u7597\u9002\u5408\u5149\u7597\u6216\u5168\u8eab\u6cbb\u7597\u7684\u4e2d\u91cd\u5ea6\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u6210\u4eba\u60a3\u8005\u3002<\/p>\n<p style=\"font-weight: 400;\">Otezla\u9002\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6d3b\u52a8\u6027\u94f6\u5c51\u75c5\u5173\u8282\u708e\u60a3\u8005\u3002<\/p>\n<p style=\"font-weight: 400;\">Otezla\u9002\u7528\u4e8e\u6cbb\u7597\u767d\u585e\u75c5\u5f15\u8d77\u7684\u6210\u4eba\u53e3\u8154\u6e83\u75a1\u60a3\u8005\u3002<\/p>\n<p style=\"font-weight: 400;\">\u00a0<strong><br \/>\n<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>Otezla<sup>\u00ae<\/sup><\/strong><strong>\uff08\u963f\u666e\u65af\u7279\uff09\u7f8e\u56fd\u91cd\u8981\u5b89\u5168\u6027\u4fe1\u606f<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>\u7981\u5fcc\u75c7<\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\">Otezla<sup>\u00ae<\/sup>\uff08\u963f\u666e\u65af\u7279\uff09\u7981\u7528\u4e8e\u5df2\u77e5\u5bf9\u963f\u666e\u65af\u7279\u6216\u5236\u5242\u4e2d\u4efb\u4f55\u8f85\u6599\u5b58\u5728\u8d85\u654f\u53cd\u5e94\u7684\u60a3\u8005<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\"><strong>\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879<\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\">\u8179\u6cfb\u3001\u6076\u5fc3\u548c\u5455\u5410\uff1a\u91cd\u5ea6\u8179\u6cfb\u3001\u6076\u5fc3\u548c\u5455\u5410\u75c5\u4f8b\u4e0e\u4f7f\u7528Otezla\u6709\u5173\u3002\u5927\u591a\u6570\u4e8b\u4ef6\u53d1\u751f\u5728\u6cbb\u7597\u7684\u524d\u51e0\u5468\u5185\u3002\u90e8\u5206\u60a3\u8005\u9700\u8981\u4f4f\u9662\u6cbb\u7597\u300265\u5c81\u6216\u4ee5\u4e0a\u7684\u60a3\u8005\u548c\u6b63\u5728\u670d\u7528\u7684\u836f\u7269\u53ef\u80fd\u5bfc\u81f4\u8840\u91cf\u7f3a\u5c11\u6216\u4f4e\u8840\u538b\u7684\u60a3\u8005\u53ef\u80fd\u66f4\u5bb9\u6613\u53d1\u751f\u4e25\u91cd\u8179\u6cfb\u3001\u6076\u5fc3\u6216\u5455\u5410\u7b49\u5e76\u53d1\u75c7\u3002\u76d1\u6d4b\u66f4\u5bb9\u6613\u53d1\u751f\u8179\u6cfb\u6216\u5455\u5410\u5e76\u53d1\u75c7\u7684\u60a3\u8005\uff1b\u5efa\u8bae\u60a3\u8005\u5728\u53d1\u751f\u6b64\u7c7b\u60c5\u51b5\u65f6\u8054\u7cfb\u5176\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u8005\u3002\u5982\u679c\u60a3\u8005\u51fa\u73b0\u91cd\u5ea6\u8179\u6cfb\u3001\u6076\u5fc3\u6216\u5455\u5410\uff0c\u8003\u8651\u964d\u4f4eOtezla\u5242\u91cf\u6216\u6682\u505c\u7ed9\u836f\u3002<\/li>\n<li style=\"font-weight: 400;\">\u6291\u90c1\uff1a\u8c28\u614e\u6743\u8861\u6709\u6291\u90c1\u548c\/\u6216\u81ea\u6740\u60f3\u6cd5\/\u884c\u4e3a\u53f2\u7684\u60a3\u8005\u6216\u5728\u4f7f\u7528Otezla\u671f\u95f4\u51fa\u73b0\u6b64\u7c7b\u75c7\u72b6\u7684\u60a3\u8005\u4f7f\u7528Otezla\u7684\u98ce\u9669\u548c\u83b7\u76ca\u3002\u5e94\u544a\u77e5\u60a3\u8005\u3001\u62a4\u7406\u8005\u548c\u5bb6\u5c5e\uff0c\u9700\u8981\u8b66\u60d5\u6291\u90c1\u3001\u81ea\u6740\u60f3\u6cd5\u6216\u5176\u4ed6\u60c5\u7eea\u53d8\u5316\u7684\u51fa\u73b0\u6216\u6076\u5316\uff0c\u5982\u679c\u53d1\u751f\u6b64\u7c7b\u53d8\u5316\uff0c\u5e94\u7acb\u5373\u8054\u7cfb\u5176\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u8005\u3002<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">o\u00a0\u00a0<u>\u94f6\u5c51\u75c5<\/u>\uff1aOtezla\u6cbb\u7597\u4e0e\u6291\u90c1\u589e\u52a0\u76f8\u5173\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\uff0c1.3%\uff0812\/920\uff09\u7684\u60a3\u8005\u62a5\u544a\u6291\u90c1\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a0.4%\uff082\/506\uff09\u3002Otezla\u7ec4\u67090.1%\uff081\/1308\uff09\u7684\u60a3\u8005\u62a5\u544a\u4e25\u91cd\u6291\u90c1\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u60a3\u8005\u672a\u62a5\u544a\uff080\/506\uff09\u3002Otezla\u7ec4\u67090.1%\uff081\/1308\uff09\u7684\u60a3\u8005\u89c2\u5bdf\u5230\u81ea\u6740\u884c\u4e3a\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a0.2%\uff081\/506\uff09\u30021\u4f8b\u63a5\u53d7Otezla\u6cbb\u7597\u7684\u60a3\u8005\u4f01\u56fe\u81ea\u6740\uff1b1\u4f8b\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u81ea\u6740\u3002<\/p>\n<p style=\"font-weight: 400;\">o\u00a0<u>\u94f6\u5c51\u75c5\u5173\u8282\u708e<\/u>\uff1aOtezla\u6cbb\u7597\u4e0e\u6291\u90c1\u589e\u52a0\u76f8\u5173\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\uff0c1.0%\uff0810\/998\uff09\u7684\u60a3\u8005\u62a5\u544a\u6291\u90c1\u6216\u5fc3\u5883\u6291\u90c1\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a0.8%\uff084\/495\uff09\u3002\u5728\u63a5\u53d7Otezla\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c0.2%\uff083\/1441\uff09\u7684\u60a3\u8005\u89c2\u5bdf\u5230\u81ea\u6740\u60f3\u6cd5\u548c\u884c\u4e3a\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u672a\u89c2\u5bdf\u5230\u81ea\u6740\u60f3\u6cd5\u548c\u884c\u4e3a\u3002Otezla\u7ec4\u67090.2%\uff083\/1441\uff09\u7684\u60a3\u8005\u62a5\u544a\u4e25\u91cd\u6291\u90c1\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u60a3\u8005\u672a\u62a5\u544a\uff080\/495\uff09\u3002\u5b89\u6170\u5242\u7ec4\u76842\u4f8b\u60a3\u8005\u81ea\u6740\uff0c\u800cOtezla\u7ec4\u65e0\u81ea\u6740\u3002<\/p>\n<p style=\"font-weight: 400;\">o\u00a0<u>\u767d\u585e\u75c5<\/u>\uff1aOtezla\u6cbb\u7597\u4e0e\u6291\u90c1\u589e\u52a0\u76f8\u5173\u3002\u5728III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\uff0c1%\uff081\/104\uff09\u7684\u60a3\u8005\u62a5\u544a\u6291\u90c1\u6216\u5fc3\u5883\u6291\u90c1\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a1%\uff081\/103\uff09\u3002Otezla\u6216\u5b89\u6170\u5242\u7ec4\u7684\u60a3\u8005\u672a\u62a5\u544a\u81ea\u6740\u60f3\u6cd5\u6216\u884c\u4e3a\u3002<\/p>\n<ul>\n<li>\u4f53\u91cd\u51cf\u8f7b\uff1a\u5b9a\u671f\u76d1\u6d4b\u4f53\u91cd\uff1b\u8bc4\u4f30\u4e0d\u660e\u539f\u56e0\u6216\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u4f53\u91cd\u51cf\u8f7b\uff0c\u5e76\u8003\u8651\u505c\u7528Otezla<\/li>\n<\/ul>\n<p style=\"font-weight: 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