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Fycompa\u662f\u7531\u536b\u6750\u72ec\u5bb6\u7814\u53d1\u7684\u4e00\u79cd\u65b0\u578b\u6297\u766b\u75eb\u836f\u7269\u3002\u766b\u75eb\u53d1\u4f5c\u662f\u7531\u795e\u7ecf\u9012\u8d28\u8c37\u6c28\u9178\u4ecb\u5bfc\u7684\u3002\u8be5\u836f\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u3001\u975e\u7ade\u4e89\u6027\u7684 AMPA \u578b\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u53ef\u901a\u8fc7\u9776\u5411\u7a81\u89e6\u540e\u7ec6\u80de\u819c\u4e0a\u7684AMPA\u53d7\u4f53\u5904\u7684\u8c37\u6c28\u9178\u6d3b\u6027\uff0c\u51cf\u5c11\u4e0e\u766b\u75eb\u53d1\u4f5c\u76f8\u5173\u7684\u795e\u7ecf\u5143\u7684\u8fc7\u5ea6\u5174\u594b\u3002\u5728\u65e5\u672c\uff0cFycompa\u9002\u7528\u4e8e4\u5c81\u53ca\u4ee5\u4e0a\u766b\u75eb\u90e8\u5206\u6027\u53d1\u4f5c(\u4f34\u6216\u4e0d\u4f34\u7ee7\u53d1\u6027\u5168\u9762\u6027\u766b\u75eb\u53d1\u4f5c)\u60a3\u8005\u7684\u5355\u836f\u6cbb\u7597\u548c\u8f85\u52a9\u6cbb\u7597\u3002\u53ca\u4f5c\u4e3a12\u5c81\u53ca\u4ee5\u4e0a\u766b\u75eb\u60a3\u8005\u7684\u539f\u53d1\u6027\u5168\u9762\u5f3a\u76f4\u9635\u631b\u53d1\u4f5c\u6027\u766b\u75eb\u7684\u8f85\u52a9\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u5728\u7f8e\u56fd\uff0cFycompa\u4e5f\u9002\u7528\u4e8e4\u5c81\u53ca\u4ee5\u4e0a\u766b\u75eb\u90e8\u5206\u6027\u53d1\u4f5c(\u4f34\u6216\u4e0d\u4f34\u7ee7\u53d1\u6027\u5168\u9762\u6027\u766b\u75eb\u53d1\u4f5c)\u60a3\u8005\u7684\u5355\u836f\u6cbb\u7597\u548c\u8f85\u52a9\u6cbb\u7597\u3002\u53ca\u4f5c\u4e3a12\u5c81\u53ca\u4ee5\u4e0a\u766b\u75eb\u60a3\u8005\u7684\u539f\u53d1\u6027\u5168\u9762\u5f3a\u76f4\u9635\u631b\u53d1\u4f5c\u6027\u766b\u75eb\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n
\u536b\u6750\u8ba4\u4e3a\u5305\u62ec\u766b\u75eb\u5728\u5185\u7684\u795e\u7ecf\u5b66\u662f\u4e00\u4e2a\u91cd\u70b9\u6cbb\u7597\u9886\u57df\u3002\u968f\u7740Fycompa\u5728\u6b27\u6d32\u7684\u4e0a\u5e02\uff0c\u536b\u6750\u81f4\u529b\u4e8e\u8ba9\u4e16\u754c\u5404\u5730\u66f4\u591a\u766b\u75eb\u60a3\u8005\u5b9e\u73b0\u201c\u96f6\u53d1\u4f5c\u201d\u7684\u76ee\u6807\u3002\u536b\u6750\u81f4\u529b\u4e8e\u6ee1\u8db3\u766b\u75eb\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u7684\u5404\u79cd\u9700\u6c42\uff0c\u5e76\u4e3a\u5176\u63d0\u4f9b\u66f4\u591a\u798f\u5229\u3002<\/p>\n
\n
\u5a92\u4f53\u54a8\u8be2\uff1a<\/strong><\/b> [\u7f16\u8005\u6ce8]<\/strong><\/p>\n Fycompa\u662f\u7531\u536b\u6750\u72ec\u5bb6\u7814\u53d1\u7684\u4e00\u79cd\u65b0\u578b\u6297\u766b\u75eb\u836f\u7269\u3002\u766b\u75eb\u53d1\u4f5c\u662f\u7531\u795e\u7ecf\u9012\u8d28\u8c37\u6c28\u9178\u4ecb\u5bfc\u7684\uff0c\u8be5\u836f\u7269\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u3001\u975e\u7ade\u4e89\u6027\u7684AMPA\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u901a\u8fc7\u9776\u5411\u7a81\u89e6\u540e\u819c\u4e0aAMPA\u53d7\u4f53\u5904\u7684\u8c37\u6c28\u9178\u76d0\u6d3b\u6027\uff0c\u51cf\u5c11\u4e0e\u766b\u75eb\u53d1\u4f5c\u76f8\u5173\u7684\u795e\u7ecf\u5143\u7684\u8fc7\u5ea6\u5174\u594b\u3002Fycompa\u5236\u5242\u73b0\u5df2\u4e0a\u5e02\u9500\u552e\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u7761\u524d\u53e3\u670d\u3002\u65e5\u672c\u5df2\u6279\u51c6\u7247\u5242\u548c\u7ec6\u9897\u7c92\u5236\u5242\u3002\u8be5\u836f\u7684\u53e3\u670d\u6df7\u60ac\u5242\u548c\u7247\u5242\u5df2\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u83b7\u5f97\u6279\u51c6\u3002<\/p>\n 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\n \u7814\u7a76311\u662f\u4e00\u9879\u5168\u7403\u6027\uff08\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u65e5\u672c\u3001\u97e9\u56fd\uff09\u5f00\u653e\u6027III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc4\u4f30Fycompa\u53e3\u670d\u6df7\u60ac\u6db2\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u836f\u7269\u7ed9\u836f\u65f6\u7528\u4e8e180\u540d4\u5c81\u81f312\u5c81\u4ee5\u4e0b\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u6216\u539f\u53d1\u6027\u5168\u8eab\u5f3a\u76f4\u9635\u631b\u53d1\u4f5c\u63a7\u5236\u4e0d\u5f53\u7684\u513f\u7ae5\u766b\u75eb\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u66b4\u9732\u7597\u6548\u5173\u7cfb\u3002\u8fd9\u9879\u7814\u7a76\u5305\u542b\u4e00\u4e2a\u6cbb\u7597\u671f\uff08\u5305\u62ec\u957f\u8fbe11\u5468\u7684\u6ef4\u5b9a\u671f\u548c\u957f\u8fbe12\u5468\u7684\u7ef4\u6301\u671f\uff09\u4ee5\u53ca\u4e00\u4e2a\u5ef6\u957f\u671f\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6bcf\u65e5\u7761\u524d\u53e3\u670d\u4e00\u6b212~16mg Fycompa\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u7597\u6548\u4e0e\u5bf912\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\u89c2\u5bdf\u5230\u7684\u76f8\u4f3c\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08\u53d1\u751f\u7387\u4e3a10%\u6216\u66f4\u9ad8\uff09\u662f\u55dc\u7761\u3001\u9f3b\u54bd\u708e\u3001\u53d1\u70ed\u3001\u5455\u5410\u3001\u5934\u6655\u3001\u6d41\u884c\u6027\u611f\u5192\u3001\u4ee5\u53ca\u6613\u6012\uff0c\u8fd9\u4e0e\u8fc4\u4eca\u4e3a\u6b62Fycompa\u7684\u5b89\u5168\u7279\u6027\u4e00\u81f4\u3002<\/p>\n \n 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\n2<\/sup>\u00a0J. Ben Renfroe et al. \u8f85\u52a9\u6cbb\u7597\u836f\u7269\u5421\u4ed1\u5e15\u5948\u53e3\u670d\u6df7\u60ac\u5242\u7528\u4e8e\u22652\u5c81\u81f3<12\u5c81\u513f\u79d1\u766b\u75eb\u60a3\u8005\uff1a\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u7597\u6548\u3002J Child Neurol2019\u5e744\u6708\uff1b\u7b2c34(5)\u671f\uff1a\u7b2c284-294\u9875
\n3<\/sup>\u00a0\u201c\u766b\u75eb\u548c\u766b\u75eb\u53d1\u4f5c\uff1a\u7814\u7a76\u671f\u671b\u3002\u4ec0\u4e48\u662f\u766b\u75eb\uff1f\u201d\u56fd\u7acb\u795e\u7ecf\u75c5\u5b66\u4e0e\u4e2d\u98ce\u7814\u7a76\u6240\uff0c2016\u5e745\u670824\u65e5\u8bbf\u95ee\uff0chttp:\/\/www.ninds.nih.gov\/disorders\/epilepsy\/detail_epilepsy.htm#230253109<\/p>\n","protected":false},"excerpt":{"rendered":"