{"id":2637,"date":"2020-09-23T00:00:00","date_gmt":"2021-03-18T01:44:55","guid":{"rendered":"https:\/\/www.9-design.net\/?p=2637"},"modified":"2021-03-18T09:44:55","modified_gmt":"2021-03-18T01:44:55","slug":"%e5%8d%ab%e6%9d%90%e5%92%8c%e9%bb%98%e6%b2%99%e4%b8%9c%e5%9c%a82020%e5%b9%b4%e6%ac%a7%e6%b4%b2%e8%82%bf%e7%98%a4%e5%86%85%e7%a7%91%e5%ad%a6%e4%bc%9a%ef%bc%88esmo%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a","status":"publish","type":"post","link":"https:\/\/www.9-design.net\/2020\/09\/23\/%e5%8d%ab%e6%9d%90%e5%92%8c%e9%bb%98%e6%b2%99%e4%b8%9c%e5%9c%a82020%e5%b9%b4%e6%ac%a7%e6%b4%b2%e8%82%bf%e7%98%a4%e5%86%85%e7%a7%91%e5%ad%a6%e4%bc%9a%ef%bc%88esmo%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a\/","title":{"rendered":"\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u57282020\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e0a\u9996\u6b21\u5c55\u793a\u4e86\u4e24\u9879\u7814\u7a76\u57287\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u8bc4\u4ef7KEYTRUDA\u00ae[\u5e15\u535a\u5229\u73e0\u5355\u6297]\u8054\u5408LENVIMA\u00ae[\u4ed1\u4f10\u66ff\u5c3c]\u7684\u6570\u636e"},"content":{"rendered":"

\u65b0\u7ed3\u679c\u5305\u62ec<\/strong>II<\/strong>\u671f<\/strong>LEAP-004<\/strong>\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u8868\u660e\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u6297<\/strong>PD-1\/PD-L1<\/strong>\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u4e0d\u53ef\u5207\u9664\u6216\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684<\/strong>ORR<\/strong>\u4e3a<\/strong>21.4%<\/strong><\/em><\/p>\n

\n

\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548cMerck & Co., Inc.\uff08Kenilworth, N.J.\uff0c\u7f8e\u56fd\uff1b\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u4ee5\u5916\u56fd\u5bb6\u548c\u5730\u533a\u79f0\u4e3aMSD\uff09\u5ba3\u5e03\u4e86LEAP\uff08\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u7cfb\u5217\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\u4e2d\u8bc4\u4ef7LENVIMA\uff08\u536b\u6750\u7814\u53d1\u7684\u53e3\u670d\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\uff09\u8054\u5408KEYTRUDA\uff08\u9ed8\u6c99\u4e1c\u516c\u53f8\u7684\u6297PD-1\u6cbb\u7597\u836f\u7269\uff09\u7684\u4e24\u9879\u8bd5\u9a8c\u7684\u6700\u65b0\u7814\u7a76\u6570\u636e\u3002\u5728II\u671fLEAP-004\u8bd5\u9a8c\u4e2d\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u6297PD-1\/PD-L1\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u4e0d\u53ef\u5207\u9664\u6216\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0cLENVIMA\u8054\u5408KEYTRUDA\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a21.4%\uff0895%\u7f6e\u4fe1\u533a\u95f4[CI]\uff1a13.9-30.5\uff09\u3002\u5728II\u671fLEAP-005\u8bd5\u9a8c\u4e2d\uff0c\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u3001\u5375\u5de2\u764c\u3001\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\uff08\u975e\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u6027[\u975eMSI-H]\/\u9519\u914d\u4fee\u590d\u57fa\u56e0\u6b63\u5e38[pMMR]\uff09\u3001\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u548c\u80c6\u7ba1\u764c\uff08BTC\uff09\u60a3\u8005\u4e2d\uff0cLENVIMA\u8054\u5408KEYTRUDA\u7684ORR\u8303\u56f4\u4e3a9.7-32.3%\uff0895% CI\uff1a2.0-51.4\uff09\u3002LEAP-004\uff08\u6458\u8981\u53f7LBA44\uff09\u548cLEAP-005\uff08\u6458\u8981\u53f7LBA41\uff09\u7684\u7ed3\u679c\u88ab2020\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u63a5\u6536\u4e3a\u5ef6\u8fdf\u516c\u5e03\u6458\u8981\uff0c\u5e76\u5728\u4f1a\u4e0a\u8fdb\u884c\u5c55\u793a\u548c\u6c47\u62a5\u3002<\/p>\n

\u9ed8\u6c99\u4e1c\u7814\u7a76\u5b9e\u9a8c\u5ba4\u4e34\u5e8a\u7814\u7a76\u526f\u603b\u88c1Scot Ebbinghaus\u535a\u58eb\u79f0\uff1a\u201c\u8fd9\u4e9b\u6765\u81eaLEAP\u4e34\u5e8a\u9879\u76ee\u7684\u65b0\u6570\u636e\u8868\u660e\uff0cKEYTRUDA\u8054\u5408LENVIMA\u5728\u51e0\u79cd\u4fb5\u88ad\u6027\u764c\u75c7\u7c7b\u578b\u4e2d\u8868\u73b0\u51fa\u9f13\u821e\u4eba\u5fc3\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8ba9\u6211\u4eec\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u4e86\u8be5\u8054\u5408\u7528\u836f\u7684\u6f5c\u529b\uff0c\u8fd9\u5c06\u5e2e\u52a9\u66f4\u591a\u60a3\u6709\u8fd9\u4e9b\u764c\u75c7\u7684\u60a3\u8005\u201d\u3002\u540c\u65f6Scot Ebbinghaus\u535a\u58eb\u4e5f\u79f0\uff1a\u201c\u8fd9\u662f\u6211\u4eec\u9996\u6b21\u5c55\u793a\u4e24\u9879LEAP\u8bd5\u9a8c\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u53cd\u6620\u4e86\u6211\u4eec\u76ee\u524d\u5728\u63a2\u7d22\u8fd9\u79cd\u8054\u5408\u7528\u836f\u5bf9\u9700\u8981\u65b0\u6cbb\u7597\u9009\u62e9\u7684\u60a3\u8005\u7684\u6f5c\u529b\uff0c\u7279\u522b\u662f\u5bf9\u90a3\u4e9b\u65e2\u5f80\u63a5\u53d7\u6297PD-1\u6216PD-L1\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u6f5c\u529b\u65b9\u9762\u6240\u53d6\u5f97\u7684\u91cd\u5927\u8fdb\u5c55\u3002\u201d<\/p>\n

\u536b\u6750\u526f\u603b\u88c1\u3001\u80bf\u7624\u4e8b\u4e1a\u90e8\u9996\u5e2d\u533b\u5b66\u521b\u65b0\u5b98\uff08Chief\u00a0 Medicine\u00a0 Creation\uff09\u517c\u9996\u5e2d\u53d1\u73b0\u5b98\uff08Chief Discovery Officer\uff09Takashi Owa\u535a\u58eb\u79f0\uff1a\u201c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u572813\u79cd\u4e0d\u540c\u764c\u75c7\u4e2d\u83b7\u5f97\u7684\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u6210\u679c\u4f7f\u6211\u4eec\u53d7\u5230\u9f13\u821e\uff0c\u8fd9\u4e9b\u7814\u7a76\u6210\u679c\u652f\u6301LENVIMA\u4e0eKEYTRUDA\u8054\u5408\u7528\u836f\u7684\u6f5c\u529b\uff0c\u76ee\u524d\uff0c\u6211\u4eec\u6b63\u572819\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5bf9\u8fd9\u79cd\u8054\u5408\u7528\u836f\u8fdb\u884c\u8bc4\u4ef7\u201d\u3002\u540c\u65f6Takashi Owa\u535a\u58eb\u4e5f\u79f0\uff1a\u201c\u8fd9\u4e9b\u6570\u636e\u4e0d\u4ec5\u6709\u52a9\u4e8e\u6211\u4eec\u52a0\u6df1\u5bf9\u6cbb\u7597\u65b9\u6848\u7684\u4e86\u89e3\uff0c\u800c\u4e14\u66f4\u52a0\u575a\u5b9a\u4e86\u6211\u4eec\u7684\u51b3\u5fc3\uff0c\u52aa\u529b\u89e3\u51b3\u8fd9\u4e9b\u60a3\u8005\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u201d<\/p>\n


\n\u4ed1\u4f10\u66ff\u5c3c\uff08<\/strong>len<\/strong>\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08<\/strong>pembro<\/strong>\uff09\u6cbb\u7597\u63a5\u53d7<\/strong>PD-1<\/strong>\u6216<\/strong>PD-L1<\/strong>\u6291\u5236\u5242\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff08<\/strong>MEL<\/strong>\uff09\uff1a<\/strong>LEAP-004<\/strong>\uff08\u6458\u8981\u53f7<\/strong>LBA44<\/strong>\uff09\u7684\u521d\u6b65\u7ed3\u679c<\/strong><\/p>\n

LEAP-004\uff08ClinicalTrials.gov\uff0cNCT03776136\uff09\u662f\u4e00\u9879\u572812\u5468\u5185\u63a5\u53d7\u6297PD-1\/PD-L1\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u4e0d\u53ef\u5207\u9664\u6216\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u8bc4\u4ef7LENVIMA\u8054\u5408KEYTRUDA\u7684II\u671f\u3001\u5355\u81c2\u3001\u5f00\u653e\u6027\u8bd5\u9a8c\u3002\u60a3\u8005\u53e3\u670dLENVIMA 20 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u540c\u65f6\u9759\u8109\u8f93\u6ce8KEYTRUDA 200 mg\uff0c\u6bcf3\u5468\u4e00\u6b21\uff0c\u6301\u7eed35\u4e2a\u5468\u671f\uff08\u7ea62\u5e74\uff09\uff0c\u76f4\u81f3\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u6216\u75be\u75c5\u8fdb\u5c55\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3aORR\uff0c\u7531\u8bbe\u76f2\u72ec\u7acb\u4e2d\u5fc3\u5ba1\u67e5\uff08BICR\uff09\u6839\u636e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST\uff09v1.1\u8fdb\u884c\u8bc4\u4f30\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\uff08\u7531BICR\u6839\u636eRECIST v1.1\u8bc4\u4f30\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4ee5\u53ca\u5b89\u5168\u6027\u3002<\/p>\n

\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff082020\u5e746\u670810\u65e5\uff09\uff0c\u5171\u6709103\u4f8b\u60a3\u8005\u5165\u7ec4\u5e76\u63a5\u53d7\u6cbb\u7597\u3002\u4e2d\u4f4d\u968f\u8bbf\u6301\u7eed\u65f6\u95f4\u4e3a12\u4e2a\u6708\uff08\u8303\u56f4\uff1a8.7-15.6\uff09\uff0cLENVIMA\u8054\u5408KEYTRUDA\u7684\u603b\u4f53ORR\uff08\u7531BICR\u8bc4\u4f30\uff09\u4e3a21.4%\uff08n=22\uff09\uff0895% CI\uff1a13.9-30.5\uff09\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a1.9%\uff08n=2\uff09\uff0c\u90e8\u5206\u7f13\u89e3\u7387\u4e3a19.4%\uff08n=20\uff09\u3002\u5728\u603b\u4f53\u7814\u7a76\u4eba\u7fa4\u4e2d\uff0c\u4e2d\u4f4dDOR\u4e3a6.3\u4e2a\u6708\uff08\u8303\u56f4\uff1a2.1+\u81f311.1+\uff09\uff0c72.6%\uff0895% CI\uff1a46.2-87.6\uff09\u7684\u60a3\u8005\u7f13\u89e3\u6301\u7eed\u81f3\u5c116\u4e2a\u6708\u3002\u4e2d\u4f4dPFS\u4e3a4.2\u4e2a\u6708\uff0895% CI\uff1a3.5-6.3\uff09\uff0c73.8%\u7684\u60a3\u8005\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\uff0c9\u4e2a\u6708PFS\u7387\u4e3a26.2%\uff0895% CI\uff1a17.4-35.9\uff09\u3002\u4e2d\u4f4dOS\u4e3a13.9\u4e2a\u6708\uff0895% CI\uff1a10.8-\u672a\u8fbe\u5230[NR]\uff09\uff0c44.7%\u7684\u60a3\u8005\u6b7b\u4ea1\uff0c9\u4e2a\u6708OS\u7387\u4e3a65.4%\uff0895% CI\uff1a55.2-73.8\uff09\u3002<\/p>\n

\u63a2\u7d22\u6027\u5206\u6790\u8868\u660e\uff0c\u5177\u4f53\u6765\u8bf4\uff0c\u5728\u63a5\u53d7\u6297PD-1\/L1\u6cbb\u7597+\u6297CTLA-4\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u768429\u4f8b\u60a3\u8005\u4e2d\uff0cORR\uff08\u7531BICR\u8bc4\u4f30\uff09\u4e3a31%\uff0895% CI\uff1a15.3-50.8\uff09\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a3.4%\uff08n=1\uff09\uff0c\u90e8\u5206\u7f13\u89e3\u7387\u4e3a27.6%\uff08n=8\uff09\u3002\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff0c\u7531BICR\u8bc4\u4f30\uff09\u4e3a62.1%\uff0895% CI\uff1a42.3-79.3\uff09\u3002\u5728\u603b\u4f53\u7814\u7a76\u4eba\u7fa4\u4e2d\uff0cDCR\uff08\u7531BICR\u8bc4\u4f30\uff09\u4e3a65%\uff0895% CI\uff1a55.0-74.2\uff09\u3002<\/p>\n

\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u5bfc\u81f47.8%\u7684\u60a3\u8005\u7ec8\u6b62LENVIMA\u548c\/\u6216KEYTRUDA\u6cbb\u7597\u300244.7%\u7684\u60a3\u8005\u53d1\u751f3-5\u7ea7TRAE\uff083\u7ea7\uff1a39.8%\uff1b4\u7ea7\uff1a3.9%\uff1b5\u7ea7\uff1a1.0%\uff09\uff0c18.4%\u7684\u60a3\u8005\u53d1\u751f\u4e25\u91cdTRAE\u3002\u603b\u4f53\u7814\u7a76\u4eba\u7fa4\u53d1\u751f\u7684\u6700\u5e38\u89c1\uff08\u226530%\uff09\u7684\u4efb\u4f55\u7ea7\u522b\u7684TRAE\u4e3a\u9ad8\u8840\u538b\uff0856.3%\uff09\u3001\u8179\u6cfb\uff0835.9%\uff09\u3001\u6076\u5fc3\uff0834.0%\uff09\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff0833.0%\uff09\u548c\u98df\u6b32\u51cf\u9000\uff0831.1%\uff09\u3002<\/p>\n


\nLEAP-005<\/strong>\uff1a\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7ecf\u6cbb\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684<\/strong>II<\/strong>\u671f\u7814\u7a76\uff08\u6458\u8981\u53f7<\/strong>LBA41<\/strong>\uff09<\/strong><\/p>\n

LEAP-005\uff08ClinicalTrials.gov\uff0cNCT03797326\uff09\u662f\u4e00\u9879\u5728\u9009\u5b9a\u65e2\u5f80\u7ecf\u6cbb\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u8bc4\u4ef7LENVIMA\u8054\u5408KEYTRUDA\u7684II\u671f\u3001\u5355\u81c2\u3001\u5f00\u653e\u6027\u8bd5\u9a8c\u3002\u7814\u7a76\u961f\u5217\u4e3aTNBC\u3001\u5375\u5de2\u764c\u3001\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\uff08\u975eMSI-H\/pMMR\uff09\u3001GBM\u548cBTC\u60a3\u8005\u3002\u60a3\u8005\u53e3\u670dLENVIMA 20 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u540c\u65f6\u9759\u8109\u8f93\u6ce8KEYTRUDA 200 mg\uff0c\u6bcf3\u5468\u4e00\u6b21\uff0c\u6301\u7eed35\u4e2a\u5468\u671f\uff08\u7ea62\u5e74\uff09\uff0c\u76f4\u81f3\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u6216\u75be\u75c5\u8fdb\u5c55\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3aORR\uff08\u7531BICR\u6839\u636eRECIST v1.1\u6216\u795e\u7ecf\u80bf\u7624\u5b66\u7597\u6548\u8bc4\u4f30[RANO]\u6807\u51c6[\u4ec5\u9002\u7528\u4e8eGBM]\u8bc4\u4f30\uff09\u548c\u5b89\u5168\u6027\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ecDCR\uff08\u7531BICR\u6839\u636eRECIST v1.1\u6216RANO[\u4ec5\u9002\u7528\u4e8eGBM]\u8bc4\u4f30\uff09\u3001DOR\uff08\u7531BICR\u6839\u636eRECIST v1.1\u6216RANO[\u4ec5\u9002\u7528\u4e8eGBM]\u8bc4\u4f30\uff09\u3001PFS\uff08\u7531BICR\u6839\u636eRECIST v1.1\u6216RANO[\u4ec5\u9002\u7528\u4e8eGBM]\u8bc4\u4f30\uff09\u4ee5\u53caOS\u3002<\/p>\n

\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff082020\u5e744\u670810\u65e5\uff09\uff0c\u5171\u6709187\u4f8b\u60a3\u8005\u5165\u7ec4\u5e76\u63a5\u53d7\u6cbb\u7597\u3002\u4e2d\u4f4d\u968f\u8bbf\u6301\u7eed\u65f6\u95f4\u4e3a8.6\u4e2a\u6708\uff08\u8303\u56f4\uff1a1.9-13.1\uff09\u65f6\uff0c6\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u8bc1\u5b9e\u7684ORR\u4ee5\u53ca\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7ed3\u679c\uff1a<\/p>\n

\u603b\u4f53\u7814\u7a76\u4eba\u7fa4\u53d1\u751f\u7684\u6700\u5e38\u89c1\uff08\u226520%\uff09\u7684\u4efb\u4f55\u7ea7\u522b\u7684TRAE\u4e3a\u9ad8\u8840\u538b\uff0839.0%\uff09\u3001\u75b2\u4e4f\uff0829.4%\uff09\u3001\u8179\u6cfb\uff0826.7%\uff09\u3001\u98df\u6b32\u51cf\u9000\uff0825.1%\uff09\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff0827.8%\uff09\u548c\u6076\u5fc3\uff0821.9%\uff09\u3002\u57fa\u4e8e\u8fd9\u4e9b\u521d\u6b65\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u5c06\u6269\u5c55\u81f3\u6bcf\u4e2a\u961f\u5217\u5165\u7ec4\u7ea6100\u4f8b\u60a3\u8005\u3002<\/p>\n

LENVIMA\u00ae<\/sup><\/strong>\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u80f6\u56ca\u7b80\u4ecb<\/strong><\/p>\n

LENVIMA\u662f\u7531\u536b\u6750\u53d1\u73b0\u5e76\u5f00\u53d1\u7684\u4e00\u79cd\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\uff0c\u53ef\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53VEGFR1\uff08FLT1\uff09\u3001VEGFR2\uff08KDR\uff09\u548cVEGFR3\uff08FLT4\uff09\u7684\u6fc0\u9176\u6d3b\u6027\u3002\u9664\u6b63\u5e38\u7ec6\u80de\u529f\u80fd\u5916\uff0cLENVIMA\u8fd8\u53ef\u6291\u5236\u4e0e\u81f4\u75c5\u6027\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u751f\u957f\u548c\u764c\u75c7\u8fdb\u5c55\u76f8\u5173\u7684\u5176\u4ed6\u6fc0\u9176\uff0c\u5305\u62ec\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53FGFR1-4\u3001\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u03b1\uff08PDGFR\u03b1\uff09\u3001KIT\u548cRET\u3002\u5728\u540c\u7cfb\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u4e0e\u4efb\u4e00\u836f\u7269\u5355\u72ec\u7ed9\u836f\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u6297PD-1\u6297\u4f53\u53ef\u51cf\u5c11\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff0c\u589e\u52a0\u6d3b\u5316\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff0c\u5e76\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u76ee\u524d\uff0cLENVIMA\u5df2\u5728\u8d85\u8fc765\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u65e5\u672c\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u5355\u836f\u7528\u4e8e\u7532\u72b6\u817a\u764c\u7684\u6cbb\u7597\uff0c\u5e76\u5728\u8d85\u8fc765\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u65e5\u672c\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u90e8\u5206\u56fd\u5bb6\u3001\u4e2d\u56fd\u548c\u4e9a\u6d32\u90e8\u5206\u5176\u4ed6\u56fd\u5bb6\uff09\u83b7\u6279\u5355\u836f\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002\u6b64\u5916\uff0cLENVIMA\u4e5f\u5728\u8d85\u8fc755\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u6d32\u90e8\u5206\u56fd\u5bb6[\u4ee5\u5546\u54c1\u540dKisplyx\u00ae<\/sup>\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c]\u548c\u4e9a\u6d32\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u540c\u65f6\uff0cLENVIMA\u4e5f\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u52a0\u62ff\u5927\u5728\u5185\u7684\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u4e0eKEYTRUDA\u8054\u5408\u7528\u836f\u6cbb\u7597\u5728\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u4e0d\u9002\u5408\u6839\u6cbb\u6027\u624b\u672f\u6216\u653e\u7597\u7684\u975e\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\u578b\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002\u8be5\u9002\u5e94\u75c7\u7684\u6301\u7eed\u6279\u51c6\u53d6\u51b3\u4e8e\u5404\u9879\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002<\/p>\n


\nKEYTRUDA\u00ae<\/sup><\/strong>\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u6ce8\u5c04\u6db2\u7b80\u4ecb<\/strong><\/p>\n

KEYTRUDA\u662f\u4e00\u79cd\u6297PD-1\u6cbb\u7597\u836f\u7269\uff0c\u901a\u8fc7\u63d0\u9ad8\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u5e2e\u52a9\u53d1\u73b0\u548c\u6297\u51fb\u80bf\u7624\u7ec6\u80de\u7684\u80fd\u529b\u53d1\u6325\u4f5c\u7528\u3002KEYTRUDA\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u963b\u65adPD-1\u4e0e\u5176\u914d\u4f53PD-L1\u548cPD-L2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6fc0\u6d3b\u53ef\u80fd\u5f71\u54cd\u80bf\u7624\u7ec6\u80de\u548c\u5065\u5eb7\u7ec6\u80de\u7684T\u6dcb\u5df4\u7ec6\u80de\u3002<\/p>\n

\u9ed8\u6c99\u4e1c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u884c\u4e1a\u5185\u89c4\u6a21\u6700\u5927\u7684\u514d\u75ab\u80bf\u7624\u5b66\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u3002\u76ee\u524d\u67091200\u591a\u9879\u5728\u591a\u79cd\u764c\u75c7\u548c\u6cbb\u7597\u73af\u5883\u4e2d\u7814\u7a76KEYTRUDA\u7684\u8bd5\u9a8c\u3002KEYTRUDA\u4e34\u5e8a\u9879\u76ee\u65e8\u5728\u4e86\u89e3KEYTRUDA\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u53ef\u80fd\u9884\u6d4b\u60a3\u8005\u4eceKEYTRUDA\u6cbb\u7597\u4e2d\u83b7\u76ca\u53ef\u80fd\u6027\u7684\u56e0\u7d20\uff0c\u5305\u62ec\u63a2\u7d22\u51e0\u79cd\u4e0d\u540c\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n


\n\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u6218\u7565\u5408\u4f5c\u7b80\u4ecb<\/strong><\/p>\n

2018\u5e743\u6708\uff0c\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u901a\u8fc7\u5176\u5b50\u516c\u53f8\u5c55\u5f00\u4e86\u4e00\u9879\u5173\u4e8eLENVIMA\u5168\u7403\u8054\u5408\u5f00\u53d1\u548c\u8054\u5408\u5546\u4e1a\u5316\u7684\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u5408\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u63a8\u5e7fLENVIMA\uff0c\u65e2\u53ef\u5355\u836f\u6cbb\u7597\u4e5f\u53ef\u4e0e\u9ed8\u6c99\u4e1c\u6297PD-1\u6cbb\u7597\u836f\u7269KEYTRUDA\u8054\u5408\u7528\u836f\u3002<\/p>\n

\u9664\u4e86\u5728\u51e0\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u6b63\u5728\u8fdb\u884c\u7684\u8bc4\u4ef7KEYTRUDA\u4e0eLENVIMA\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u7814\u7a76\u5916\uff0c\u516c\u53f8\u8fd8\u901a\u8fc7LEAP\uff08\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u4e34\u5e8a\u9879\u76ee\u5171\u540c\u53d1\u4e86\u8d77\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u6b63\u572813\u79cd\u80bf\u7624\u7c7b\u578b\uff08\u5b50\u5bab\u5185\u819c\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u80c6\u9053\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u5375\u5de2\u764c\u548c\u4e09\u9634\u6027\u4e73\u817a\u764c\uff09\u4e2d\u901a\u8fc719\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5bf9\u8be5\u8054\u5408\u7528\u836f\u8fdb\u884c\u8bc4\u4ef7\u3002<\/p>\n

\u536b\u6750\u4e13\u6ce8\u4e8e\u764c\u75c7<\/strong><\/p>\n

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\n\u536b\u6750\u7b80\u4ecb<\/strong><\/p>\n

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