\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u5df2\u786e\u8ba4\u53d7\u7406\u536b\u6750\u81ea\u4e3b\u7814\u53d1\u7684\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff08\u4ea7\u54c1\u540d\u79f0\uff1aLENVIMA\u00ae\/Kisplyx\u00ae\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u4ed1\u4f10\u66ff\u5c3c\u201d\uff09\u8054\u5408MSD\u7814\u53d1\u7684\u6297PD-1\u836f\u7269\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u5546\u54c1\u540d\uff1aKEYTRUDA\u00ae\uff09\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u548c\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\uff08EC\uff09\u7684\u5ba1\u8bc4\u7533\u8bf7\u3002<\/p>\n
\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597RCC\u9002\u5e94\u75c7\u7684\u7533\u8bf7\u662f\u57fa\u4e8e\u665a\u671fRCC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u5173\u952e\u6027III\u671fCLEAR\u7814\u7a76\uff08\u7814\u7a76307\/KEYNOTE-581\uff09\u7684\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u57282021\u5e74\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u764c\u75c7\u7814\u8ba8\u4f1a\uff08ASCO GU\uff09\u4e0a\u516c\u5e03\uff0c\u5e76\u540c\u671f\u53d1\u8868\u4e8e2021\u5e742\u6708\u7684\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u3002\u5728\u8be5\u8bd5\u9a8c\u4e2d\uff0c\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u4e0e\u5355\u7528\u8212\u5c3c\u66ff\u5c3c\u76f8\u6bd4\uff0c\u5728\u4e3b\u8981\u7ec8\u70b9\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4ee5\u53ca\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u65b9\u9762\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002<\/p>\n
\u6b64\u5916\uff0c\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597EC\u9002\u5e94\u75c7\u7684\u7533\u8bf7\u662f\u57fa\u4e8e\u5173\u952e\u6027III\u671f\u7814\u7a76309\/KEYNOTE-775\u7684\u7ed3\u679c\uff08\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u5728\u4efb\u4f55\u80cc\u666f\u4e0b\u63a5\u53d7\u8fc7\u4e00\u79cd\u542b\u94c2\u5316\u7597\u65b9\u6848\u4e4b\u540e\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u4e8e2021\u5e743\u6708\u57282021\u5e74\u7f8e\u56fd\u5987\u79d1\u80bf\u7624\u5b66\u4f1a\uff08SGO\uff09\u5973\u6027\u764c\u75c7\u5e74\u4f1a\u4e0a\u53d1\u8868\u3002\u5728\u8be5\u8bd5\u9a8c\u4e2d\uff0c\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u4e0e\u5316\u7597\uff08\u533b\u751f\u9009\u62e9\u7684\u591a\u67d4\u6bd4\u661f\u6216\u7d2b\u6749\u9187\uff09\u76f8\u6bd4\uff0c\u5728\u4e3b\u8981\u7ec8\u70b9PFS\u548cOS\u4ee5\u53ca\u6b21\u8981\u7ec8\u70b9ORR\u65b9\u9762\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002<\/p>\n
\u8fd9\u4e9b\u7814\u7a76\u4e2d\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u65e2\u5f80\u7814\u7a76\u62a5\u544a\u7684\u7279\u5f81\u5927\u4f53\u4e00\u81f4\u3002<\/p>\n
\u636e\u4f30\u8ba1\uff0c2020\u5e74\u5168\u7403\u65b0\u8bca\u65ad\u80be\u764c\u75c5\u4f8b\u8d85\u8fc7430,000\u4f8b\uff0c\u6709\u63a5\u8fd1180,000\u4eba\u6b7b\u4e8e\u8be5\u75be\u75c51\u3002\u5728\u6b27\u6d32\uff0c2020\u5e74\u65b0\u8bca\u65ad\u75c5\u4f8b\u8d85\u8fc7138,000\u4f8b\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u8d85\u8fc754,000\u4f8b1\u3002RCC\u662f\u76ee\u524d\u6700\u5e38\u89c1\u7684\u80be\u764c\u7c7b\u578b\uff1b10\u4f8b\u80be\u764c\u4e2d\u7ea69\u4f8b\u4e3aRCC2\u3002\u7ea630%\u7684RCC\u60a3\u8005\u5728\u8bca\u65ad\u65f6\u5373\u5df2\u8f6c\u79fb\uff0c\u591a\u8fbe40%\u7684\u60a3\u8005\u5728\u56e0\u5c40\u9650\u6027RCC\u63a5\u53d7\u521d\u6b21\u624b\u672f\u6cbb\u7597\u540e\u53d1\u751f\u8f6c\u79fb3,4\u3002<\/p>\n
\u636e\u4f30\u8ba1\uff0c2020\u5e74\u5168\u7403\u65b0\u8bca\u65ad\u5b50\u5bab\u4f53\u764c\u75c5\u4f8b\u8d85\u8fc7417,000\u4f8b\uff0c\u6709\u63a5\u8fd197,000\u4eba\u6b7b\u4e8e\u8be5\u75be\u75c55\u3002\u5728\u6b27\u6d32\uff0c2020\u5e74\u65b0\u8bca\u65ad\u75c5\u4f8b\u8d85\u8fc7130,000\u4f8b\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u8d85\u8fc729,000\u4f8b5\u3002EC\u662f\u6700\u5e38\u89c1\u7684\u5b50\u5bab\u4f53\u764c\u7c7b\u578b\u3002\u8ba4\u4e3a90%\u4ee5\u4e0a\u7684\u5b50\u5bab\u4f53\u764c\u53d1\u751f\u5728\u5b50\u5bab\u5185\u819c6\u3002<\/p>\n
\u751f\u5b58\u7387\u56e0\u8bca\u65ad\u5206\u671f\u4e0d\u540c\u800c\u6709\u5f88\u5927\u5dee\u5f02\uff0c\u8f6c\u79fb\u6027RCC\u548c\u8f6c\u79fb\u6027EC\u7684\u4e94\u5e74\u751f\u5b58\u7387\u5206\u522b\u4e3a12%\u548c17%\u3002\u4e24\u79cd\u75be\u75c5\u9884\u540e\u5747\u8f83\u5dee\u3002<\/p>\n
2018\u5e743\u6708\uff0c\u536b\u6750\u548cMSD\u901a\u8fc7\u4e00\u5bb6\u9644\u5c5e\u516c\u53f8\uff0c\u9488\u5bf9\u4ed1\u4f10\u66ff\u5c3c\u5355\u836f\u6cbb\u7597\u4ee5\u53ca\u4e0eMSD\u7684\u6297PD-1\u836f\u7269\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u7684\u5168\u7403\u5171\u540c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002<\/p>\n
\u536b\u6750\u5c06\u80bf\u7624\u9886\u57df\u5b9a\u4f4d\u4e3a\u5173\u952e\u6cbb\u7597\u9886\u57df\uff0c\u65e8\u5728\u53d1\u73b0\u5177\u6709\u6cbb\u6108\u764c\u75c7\u6f5c\u529b\u7684\u9769\u547d\u6027\u65b0\u836f\u3002\u536b\u6750\u81f4\u529b\u4e8e\u63a2\u7d22\u4ed1\u4f10\u66ff\u5c3c\u7684\u6f5c\u5728\u4e34\u5e8a\u76ca\u5904\uff0c\u4e3a\u8fdb\u4e00\u6b65\u6ee1\u8db3\u764c\u75c7\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u548c\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u7684\u591a\u6837\u5316\u9700\u6c42\uff0c\u5e76\u63d0\u9ad8\u4ed6\u4eec\u7684\u798f\u7949\u800c\u505a\u51fa\u52aa\u529b\u3002<\/p>\n
\u5a92\u4f53\u54a8\u8be2\uff1a
\n\u536b\u6750\u682a\u5f0f\u4f1a\u793e
\n\u516c\u5171\u5173\u7cfb\u90e8
\n+81-(0)3-3817-5120<\/p>\n
[\u7f16\u8005\u6ce8]<\/p>\n
1.\u5173\u4e8e\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff08\u4ea7\u54c1\u540d\u79f0\uff1aLENVIMA\/Kisplyx\uff09<\/p>\n
\u4ed1\u4f10\u66ff\u5c3c\u662f\u7531\u536b\u6750\u53d1\u73b0\u5e76\u5f00\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u591a\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53VEGFR1\uff08FLT1\uff09\u3001VEGFR2\uff08KDR\uff09\u548cVEGFR3\uff08FLT4\uff09\u7684\u6fc0\u9176\u6d3b\u6027\u3002\u9664\u6b63\u5e38\u7ec6\u80de\u529f\u80fd\u5916\uff0c\u4ed1\u4f10\u66ff\u5c3c\u8fd8\u53ef\u6291\u5236\u4e0e\u81f4\u75c5\u6027\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u751f\u957f\u548c\u764c\u75c7\u8fdb\u5c55\u76f8\u5173\u7684\u5176\u4ed6\u6fc0\u9176\uff0c\u5305\u62ec\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53FGFR1-4\u3001\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u03b1\uff08PDGFR\u03b1\uff09\u3001KIT\u548cRET\u3002<\/p>\n
\u5728\u540c\u7cfb\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u4e0e\u4efb\u4e00\u836f\u7269\u5355\u72ec\u7ed9\u836f\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\u53ef\u51cf\u5c11\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u589e\u52a0\u6d3b\u5316\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n
\u76ee\u524d\uff0c\u4ed1\u4f10\u66ff\u5c3c\u5df2\u5728\u8d85\u8fc770\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u5355\u836f\u7528\u4e8e\u7532\u72b6\u817a\u764c\u7684\u6cbb\u7597\uff0c\u5e76\u5728\u7f8e\u56fd\u83b7\u6279\u5355\u836f\u7528\u4e8e\u653e\u5c04\u6027\u7898\u96be\u6cbb\u6027\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u7684\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u4ed1\u4f10\u66ff\u5c3c\u5df2\u5728\u8d85\u8fc765\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u65e5\u672c\u3001\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u5355\u836f\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002\u5728\u8d85\u8fc760\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\uff0c\u4ed1\u4f10\u66ff\u5c3c\u8fd8\u88ab\u6279\u51c6\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u836f\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u66fe\u63a5\u53d7\u8fc7\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u7684\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u5728\u6b27\u6d32\uff0c\u4ed1\u4f10\u66ff\u5c3c\u4ee5\u5546\u54c1\u540dKisplyx\u00ae\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3002\u540c\u65f6\uff0c\u4ed1\u4f10\u66ff\u5c3c\u4e5f\u5728\u8d85\u8fc710\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u548c\u6fb3\u5927\u5229\u4e9a\uff09\u83b7\u6279\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3001\u4e0d\u9002\u5408\u6839\u6cbb\u6027\u624b\u672f\u6216\u653e\u7597\u7684\u975e\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002\u8be5\u9002\u5e94\u75c7\u7684\u6301\u7eed\u6279\u51c6\u53d6\u51b3\u4e8e\u5404\u9879\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002Lenvima\u5728\u65e5\u672c\u4e5f\u88ab\u6279\u51c6\u5355\u836f\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u80f8\u817a\u764c\u7684\u6cbb\u7597\u3002<\/p>\n
2.\u5173\u4e8eCLEAR\u7814\u7a76\uff08\u7814\u7a76307\/KEYNOTE-581\uff09<\/p>\n
CLEAR\u7814\u7a76\uff08\u7814\u7a76307\/KEYNOTE-581\uff09\u662f\u4e00\u9879\u8bc4\u4ef7\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6216\u4f9d\u7ef4\u83ab\u53f8\u5bf9\u6bd4\u8212\u5c3c\u66ff\u5c3c\u7528\u4e8e\u665a\u671fRCC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684III\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6027\u8bd5\u9a8c\uff08ClinicalTrials.gov\uff0cNCT02811861\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u7531\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\u6839\u636e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST\uff091.1\u7248\u8bc4\u4f30\u7684PFS\u3002\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5305\u62ecOS\u3001ORR\u548c\u5b89\u5168\u6027\u3002\u5171\u67091069\u4f8b\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u81f3\u4e09\u4e2a\u6cbb\u7597\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\uff0820 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08200 mg\uff0c\u9759\u8109\u6ce8\u5c04\uff0c\u6bcf\u4e09\u5468\u4e00\u6b21\uff09\uff1b\u4ed1\u4f10\u66ff\u5c3c\uff0818 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\uff085 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\uff1b\u6216\u8212\u5c3c\u66ff\u5c3c\uff0850 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u6cbb\u75974\u5468\uff0c\u968f\u540e\u505c\u836f2\u5468\uff09\u3002<\/p>\n
\u5bf9\u4e8e\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\u6839\u636eRECIST v1.1\u8bc4\u4f30\u7684\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9PFS\uff0c\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u6bd4\u8212\u5c3c\u66ff\u5c3c\u7ec4\u964d\u4f4e61%\uff08HR=0.39 [95% CI\uff1a0.32-0.49]\uff1bp<0.001\uff09\uff0c\u4e2d\u4f4dPFS\u4e3a23.9\u4e2a\u6708\uff0895% CI\uff1a20.8-27.7\uff09\uff0c\u800c\u63a5\u53d7\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e2d\u4f4dPFS\u4e3a9.2\u4e2a\u6708\uff0895% CI\uff1a6.0-11.0\uff09\u3002\u5bf9\u4e8e\u8bd5\u9a8c\u7684\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u4e0e\u63a5\u53d7\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u7684\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e34%\uff08HR=0.66 [95% CI\uff1a0.49-0.88]\uff1bp=0.005\uff09\u3002\u4e2d\u4f4d\u968f\u8bbf27\u4e2a\u6708\u540e\uff0c\u4efb\u4e00\u6cbb\u7597\u7ec4\u5747\u672a\u8fbe\u5230\u4e2d\u4f4dOS\u3002\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684ORR\u4e3a71.0%\uff0895% CI\uff1a66.3-75.7\uff09\uff0c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u4e3a16.1%\uff0c\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u7387\u4e3a54.9%\uff0c\u800c\u63a5\u53d7\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u7684ORR\u4e3a36.1%\uff0895% CI\uff1a31.2-41.1\uff09\uff0cCR\u7387\u4e3a4.2%\uff0cPR\u7387\u4e3a31.9%\uff08\u76f8\u5bf9\u98ce\u9669=1.97 [95% CI\uff1a1.69-2.29]\uff09\u3002\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u4e3a25.8\u4e2a\u6708\uff0895% CI\uff1a22.1-27.9\uff09\uff0c\u800c\u63a5\u53d7\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u7684DOR\u4e3a14.6\u4e2a\u6708\uff0895% CI\uff1a9.4-16.7\uff09\u3002\n\n\u5728\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u4e2d\uff0c\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u5bfc\u81f418.5%\u7684\u60a3\u8005\u505c\u7528\u4ed1\u4f10\u66ff\u5c3c\uff0c25.0%\u7684\u60a3\u8005\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c9.7%\u7684\u60a3\u8005\u505c\u7528\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002\u5728\u8212\u5c3c\u66ff\u5c3c\u7ec4\u4e2d\uff0cTRAE\u5bfc\u81f410.0%\u7684\u60a3\u8005\u505c\u7528\u8212\u5c3c\u66ff\u5c3c\u3002\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec41.1%\u7684\u60a3\u8005\u548c\u8212\u5c3c\u66ff\u5c3c\u7ec40.3%\u7684\u60a3\u8005\u53d1\u751f\u4e865\u7ea7TRAE\u3002\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec471.6%\u7684\u60a3\u8005\u548c\u8212\u5c3c\u66ff\u5c3c\u7ec458.8%\u7684\u60a3\u8005\u53d1\u751f\u4e86\u22653\u7ea7TRAE\u3002\u5728\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u4e2d\uff0c\u81f3\u5c1120%\u7684\u60a3\u8005\u53d1\u751f\u7684\u6700\u5e38\u89c1TRAE\uff08\u4efb\u4f55\u7ea7\u522b\uff09\u4e3a\u8179\u6cfb\uff0854.5%\uff09\u3001\u9ad8\u8840\u538b\uff0852.3%\uff09\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff0842.6%\uff09\u3001\u98df\u6b32\u51cf\u9000\uff0834.9%\uff09\u3001\u75b2\u4e4f\uff0832.1%\uff09\u548c\u53e3\u8154\u9ecf\u819c\u708e\uff0832.1%\uff09\u3002\u5728\u8212\u5c3c\u66ff\u5c3c\u7ec4\u4e2d\uff0c\u81f3\u5c1120%\u7684\u60a3\u8005\u53d1\u751f\u7684\u6700\u5e38\u89c1TRAE\uff08\u4efb\u4f55\u7ea7\u522b\uff09\u4e3a\u8179\u6cfb\uff0844.4%\uff09\u3001\u9ad8\u8840\u538b\uff0839.1%\uff09\u3001\u53e3\u8154\u9ecf\u819c\u708e\uff0837.4%\uff09\u3001\u624b\u8db3\u7efc\u5408\u5f81\uff0835.9%\uff09\u3001\u75b2\u4e4f\uff0832.1%\uff09\u548c\u6076\u5fc3\uff0827.6%\uff09\u3002\n\n \n\n3.\u5173\u4e8e\u7814\u7a76309\/KEYNOTE-775 \n\n\u7814\u7a76309\/KEYNOTE-775\u662f\u4e00\u9879\u8bc4\u4ef7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7528\u4e8e\u65e2\u5f80\u5728\u4efb\u4f55\u80cc\u666f\u4e0b\u63a5\u53d7\u8fc7\u4e00\u79cd\u542b\u94c2\u5316\u7597\u65b9\u6848\u7684\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6027\u3001III\u671f\u8bd5\u9a8c\uff08ClinicalTrials.gov\uff0cNCT03517449\uff09\u3002\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08BICR\uff09\u6839\u636eRECIST v1.1\u8bc4\u4f30\u7684\u53cc\u91cd\u4e3b\u8981\u7ec8\u70b9\u4e3aPFS\u548cOS\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ecBICR\u6839\u636eRECIST v1.1\u9009\u62e9\u7684ORR\u4ee5\u53ca\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u3002\u5728\u5165\u7ec4\u7684827\u4f8b\u60a3\u8005\u4e2d\uff0c697\u4f8b\u60a3\u8005\u5c5e\u4e8e\u9519\u914d\u4fee\u590d\u5b8c\u6574\u578b\uff08pMMR\uff09\uff0c130\u4f8b\u60a3\u8005\u5c5e\u4e8e\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u3002\u60a3\u8005\u4ee51:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\uff0820 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08200 mg\uff0c\u9759\u8109[IV]\u6ce8\u5c04\uff0c\u6bcf3\u5468\u4e00\u6b21\uff09\u6cbb\u7597\u6700\u957f35\u4e2a\u5468\u671f\uff08\u7ea62\u5e74\uff09\uff1b\u6216\u533b\u751f\u9009\u62e9\u7684\u5316\u7597\u836f\u7269\uff08TPC\uff09\uff1a\u591a\u67d4\u6bd4\u661f\uff0860 mg\/m2 IV\uff0c\u6bcf3\u54681\u6b21\uff0c\u6700\u5927\u7d2f\u79ef\u5242\u91cf\u4e3a500 mg\/m2\uff09\u6216\u7d2b\u6749\u9187\uff0880 mg\/m2 IV\uff0c\u6bcf28\u5929\u4e3a\u4e00\u4e2a\u5468\u671f [\u8fde\u7eed3\u5468\u6bcf\u5468\u4e00\u6b21\u7d2b\u6749\u9187\u7ed9\u836f\uff0c\u505c\u836f1\u5468]\uff09\u3002\n\n\u672c\u7814\u7a76\u5728\u6240\u6709\u5165\u7ec4\u4eba\u7fa4\uff08pMMR\u548cdMMR\uff09\u548cpMMR\u4e9a\u7ec4\u4e2d\u5747\u8fbe\u5230\u53cc\u91cd\u4e3b\u8981\u7ec8\u70b9PFS\uff08BICR\u6839\u636eRECIST v1.1\u8bc4\u4f30\uff09\u548cOS\u4ee5\u53ca\u6b21\u8981\u6709\u6548\u6027\u7ec8\u70b9ORR\uff08BICR\u6839\u636eRECIST v1.1\u8bc4\u4f30\uff09\u3002\u6240\u6709\u5165\u7ec4\u4eba\u7fa4\u548cpMMR\u4e9a\u7ec4\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u5747\u4e3a11.4\u4e2a\u6708\u3002\u5728\u6240\u6709\u5165\u7ec4\u4eba\u7fa4\u4e2d\u89c2\u5bdf\u5230PFS\u51fa\u73b0\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\uff0c\u5176\u4e2d\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\uff08n=411\uff09\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e44%\uff08HR=0.56 [95% CI\uff1a0.47-0.66]\uff1bp<0.0001\uff09\uff0c\u4e2d\u4f4dPFS\u4e3a7.2\u4e2a\u6708\uff0895% CI\uff1a5.7-7.6\uff1b\u4e8b\u4ef6\u6570=281\uff09\uff0c\u800c\u63a5\u53d7TPC\u7684\u60a3\u8005\uff08n=416\uff09\u7684\u4e2d\u4f4dPFS\u4e3a3.8\u4e2a\u6708\uff0895% CI\uff1a3.6-4.2\uff1b\u4e8b\u4ef6\u6570=286\uff09\u3002\u6b64\u5916\uff0c\u5728\u6240\u6709\u5165\u7ec4\u4eba\u7fa4\u4e2d\u89c2\u5bdf\u5230OS\u51fa\u73b0\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\uff0c\u5176\u4e2d\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u7684\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e38%\uff08HR=0.62 [95% CI\uff1a0.51-0.75]\uff1bp<0.0001\uff09\uff0c\u4e2d\u4f4dOS\u4e3a18.3\u4e2a\u6708\uff0895% CI\uff1a15.2-20.5\uff1b\u4e8b\u4ef6\u6570=188\uff09\uff0c\u800c\u63a5\u53d7TPC\u7684\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4e3a11.4\u4e2a\u6708\uff0895% CI\uff1a10.5-12.9\uff1b\u4e8b\u4ef6\u6570=245\uff09\u3002\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u4e24\u79cd\u5355\u836f\u6cbb\u7597\u7684\u65e2\u5b9a\u5b89\u5168\u6027\u7279\u5f81\u5927\u4f53\u4e00\u81f4\u3002\n\n\u5728\u6240\u6709\u5165\u7ec4\u4eba\u7fa4\u4e2d\uff0c\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684\u6b21\u8981\u6709\u6548\u6027\u7ec8\u70b9ORR\u4e3a31.9%\uff0895% CI\uff1a27.4-36.6\uff09\uff0cCR\u7387\u4e3a6.6%\uff0cPR\u7387\u4e3a25.3%\uff0c\u63a5\u53d7TPC\u7684\u60a3\u8005\u7684ORR\u4e3a14.7%\uff0895% CI\uff1a11.418.4\uff09\uff0cCR\u7387\u4e3a2.6%\uff0cPR\u7387\u4e3a12.0%\uff08ORR\u4e0eTPC\u7ec4\u7684\u5dee\u5f02\u4e3a17.2\u4e2a\u767e\u5206\u70b9\uff1bp<0.0001\uff09\u3002\u5bf9\u4e8e\u7f13\u89e3\u60a3\u8005\uff0c\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u4e3a14.4\u4e2a\u6708\uff08\u8303\u56f4\uff1a1.6-23.7\uff09\uff0c\u800c\u63a5\u53d7TPC\u7684\u60a3\u8005\u4e3a5.7\u4e2a\u6708\uff08\u8303\u56f4\uff1a0.0-24.2\uff09\u3002\n\n\u6240\u6709\u5165\u7ec4\u4eba\u7fa4\u548cpMMR\u4e9a\u7ec4\u7684\u7ed3\u679c\u76f8\u4f3c\u3002\u5728pMMR\u4e9a\u7ec4\u4e2d\uff0c\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e40%\uff08HR=0.60 [95% CI\uff1a0.50-0.72]\uff1bp<0.0001\uff09\uff0c\u4e2d\u4f4dPFS\u4e3a6.6\u4e2a\u6708\uff0895% CI\uff1a5.6-7.4\uff1b\u4e8b\u4ef6\u6570=247\uff09\uff0c\u800c\u63a5\u53d7TPC\u7684\u60a3\u8005\u7684\u4e2d\u4f4dPFS\u4e3a3.8\u4e2a\u6708\uff0895% CI\uff1a3.6-5.0\uff1b\u4e8b\u4ef6\u6570=238\uff09\u3002\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u7684\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e32%\uff08HR=0.68 [95% CI\uff1a0.56-0.84]\uff1bp=0.0001\uff09\uff0c\u4e2d\u4f4dOS\u4e3a17.4\u4e2a\u6708\uff0895% CI\uff1a14.2-19.9\uff1b\u4e8b\u4ef6\u6570=165\uff09\uff0c\u800c\u63a5\u53d7TPC\u7684\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4e3a12.0\u4e2a\u6708\uff0895% CI\uff1a10.8-13.3\uff1b\u4e8b\u4ef6\u6570=203\uff09\u3002\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684\u6b21\u8981\u7ec8\u70b9ORR\u4e3a30.3%\uff0895% CI\uff1a25.5-35.5\uff09\uff0cCR\u7387\u4e3a5.2%\uff0cPR\u7387\u4e3a25.1%\uff0c\u800c\u63a5\u53d7TPC\u7684\u60a3\u8005\u7684ORR\u4e3a15.1%\uff0895% CI\uff1a11.5-19.3\uff09\uff0cCR\u7387\u4e3a2.6%\uff0cPR\u7387\u4e3a12.5%\uff08ORR\u4e0eTPC\u7ec4\u7684\u5dee\u5f02\u4e3a15.2\u4e2a\u767e\u5206\u70b9\uff1bp<0.0001\uff09\u3002\u5bf9\u4e8e\u7f13\u89e3\u60a3\u8005\uff0c\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e2d\u4f4dDOR\u4e3a9.2\u4e2a\u6708\uff08\u8303\u56f4\uff1a1.6-23.7\uff09\uff0c\u800c\u63a5\u53d7TPC\u7684\u60a3\u8005\u7684\u4e2d\u4f4dDOR\u4e3a5.7\u4e2a\u6708\uff08\u8303\u56f4\uff1a0.0-24.2\uff09\u3002\n\n\u5728\u6240\u6709\u5165\u7ec4\u4eba\u7fa4\u4e2d\uff0c\u5728\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\uff08n=406\uff09\u4e2d\uff0c\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\uff08\u4efb\u4f55\u7ea7\u522b\uff09\u5bfc\u81f430.8%\u7684\u60a3\u8005\u505c\u7528\u4ed1\u4f10\u66ff\u5c3c\uff0c18.7%\u7684\u60a3\u8005\u505c\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c14.0%\u7684\u60a3\u8005\u505c\u7528\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u3002\u5728TPC\u7ec4\u4e2d\uff08n=388\uff09\uff0cTEAE\uff08\u4efb\u4f55\u7ea7\u522b\uff09\u5bfc\u81f48.0%\u7684\u60a3\u8005\u7ec8\u6b62\u5316\u7597\u3002\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec45.7%\u7684\u60a3\u8005\u548cTPC\u7ec44.9%\u7684\u60a3\u8005\u53d1\u751f\u4e865\u7ea7TEAE\uff08\u4efb\u4f55\u539f\u56e0\uff09\u3002\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec488.9%\u7684\u60a3\u8005\u548cTPC\u7ec472.7%\u7684\u60a3\u8005\u53d1\u751f\u4e86\u22653\u7ea7TEAE\u3002\u5728\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u4e2d\uff0c\u81f3\u5c1125%\u7684\u60a3\u8005\u53d1\u751f\u7684\u6700\u5e38\u89c1TEAE\uff08\u4efb\u4f55\u7ea7\u522b\uff09\u4e3a\u9ad8\u8840\u538b\uff0864.0%\uff09\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff0857.4%\uff09\u3001\u8179\u6cfb\uff0854.2%\uff09\u3001\u6076\u5fc3\uff0849.5%\uff09\u3001\u98df\u6b32\u51cf\u9000\uff0844.8%\uff09\u3001\u5455\u5410\uff0836.7%\uff09\u3001\u4f53\u91cd\u51cf\u8f7b\uff0834.0%\uff09\u3001\u75b2\u4e4f\uff0833.0%\uff09\u3001\u5173\u8282\u75db\uff0830.5%\uff09\u3001\u86cb\u767d\u5c3f\uff0828.8%\uff09\u3001\u8d2b\u8840\uff0826.1%\uff09\u3001\u4fbf\u79d8\uff0825.9%\uff09\u548c\u5c3f\u8def\u611f\u67d3\uff0825.6%\uff09\u3002\u5728TPC\u7ec4\u4e2d\uff0c\u81f3\u5c1125%\u7684\u60a3\u8005\u53d1\u751f\u7684\u6700\u5e38\u89c1TEAE\uff08\u4efb\u4f55\u7ea7\u522b\uff09\u4e3a\u8d2b\u8840\uff0848.7%\uff09\u3001\u6076\u5fc3\uff0846.1%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0833.8%\uff09\u3001\u8131\u53d1\uff0830.9%\uff09\u548c\u75b2\u4e4f\uff0827.6%\uff09\u3002\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u7ec4\u7684\u4e2d\u4f4d\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u4e3a231\u5929\uff08\u8303\u56f4\uff1a1-817\uff09\uff0cTPC\u7ec4\u7684\u4e2d\u4f4d\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u4e3a104.5\u5929\uff08\u8303\u56f4\uff1a1-785\u5929\uff09\u3002\n\n \n\n4.\u5173\u4e8eMSD\u548c\u536b\u6750\u7684\u6218\u7565\u5408\u4f5c\n\n2018\u5e743\u6708\uff0c\u536b\u6750\u548cMSD\u901a\u8fc7\u4e00\u5bb6\u9644\u5c5e\u516c\u53f8\uff0c\u5c31\u4ed1\u4f10\u66ff\u5c3c\u7684\u5168\u7403\u5171\u540c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u5408\u5f00\u53d1\u3001\u751f\u4ea7\u4ed1\u4f10\u66ff\u5c3c\u5e76\u5c06\u5176\u5546\u4e1a\u5316\u3002\u4ed1\u4f10\u66ff\u5c3c\u65e2\u53ef\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\uff0c\u4e5f\u53ef\u4e0eMSD\u7684\u6297PD-1\u6cbb\u7597\u836f\u7269\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u3002\n\n\u9664\u4e86\u5728\u51e0\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u6b63\u5728\u8fdb\u884c\u7684\u8bc4\u4ef7\u4ed1\u4f10\u66ff\u5c3c+\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\u5916\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u901a\u8fc7LEAP\uff08\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u4e34\u5e8a\u9879\u76ee\u5171\u540c\u53d1\u8d77\u4e86\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u8bc4\u4ef7\u8054\u5408\u6cbb\u7597\uff0c\u6d89\u53ca20\u4f59\u9879\u4e34\u5e8a\u8bd5\u9a8c\u300114\u79cd\u80bf\u7624\u7c7b\u578b\uff08\u5b50\u5bab\u5185\u819c\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u80c6\u9053\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\u548c\u4e09\u9634\u6027\u4e73\u817a\u764c\uff09\u3002\n\n \n\n5.\u536b\u6750\u4e13\u6ce8\u4e8e\u764c\u75c7\n\n\u536b\u6750\u4e13\u6ce8\u4e8e\u6297\u764c\u836f\u7269\u7684\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08\u4ece\u73b0\u6709\u7684\u81ea\u4e3b\u7814\u53d1\u7684\u5316\u5408\u7269\u4e2d\u5f97\u5230\u4e86\u5927\u91cf\u7684\u7ecf\u9a8c\u548c\u77e5\u8bc6\uff0c\u4f8b\u5982\u7532\u78fa\u9178\u827e\u7acb\u5e03\u6797[\u5546\u54c1\u540d\uff1aHalaven\u00ae]\u548c\u4ed1\u4f10\u66ff\u5c3c\uff09\u4ee5\u53ca\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u53ca\u5f02\u5e38\u526a\u63a5\u7684\u56e0\u7d20\uff08\u5229\u7528RNA\u526a\u5207\u5e73\u53f0\uff09\u7b49\u9886\u57df\uff08Ricchi\uff09\uff0c\u5728\u8fd9\u4e9b\u9886\u57df\uff0c\u8fd8\u6709\u5f88\u591a\u60a3\u8005\u7684\u9700\u6c42\u672a\u5f97\u5230\u771f\u6b63\u7684\u6ee1\u8db3\uff0c\u536b\u6750\u5e0c\u671b\u6210\u4e3a\u80bf\u7624\u5b66\u9886\u57df\u7684\u9886\u5bfc\u8005\u3002\u536b\u6750\u5e0c\u671b\u4ece\u8fd9\u4e9bRicchi\u4e2d\u53d1\u73b0\u5177\u6709\u65b0\u9776\u70b9\u3001\u65b0\u4f5c\u7528\u673a\u5236\u5e76\u6709\u671b\u6cbb\u6108\u764c\u75c7\u7684\u521b\u65b0\u836f\u3002\n\n \n\n1 \u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff0c\u300a\u80be\u764c\u7b80\u62a5\u300bCancer Today\uff0c2020\u5e74\u3002\nhttps:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/29-Kidney-fact-sheet.pdf.\n\n2 \u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff0c\u300a\u6709\u5173\u80be\u764c\u7684\u5173\u952e\u7edf\u8ba1\u6570\u636e\u300b\nhttps:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-statistics.html.\n\n3 Thomas A. Z. et al. \u8f6c\u79fb\u7624\u5207\u9664\u672f\u5728\u80be\u7ec6\u80de\u764c\u4f34\u8089\u7624\u6837\u5206\u5316\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\uff1a\u5339\u914d\u5bf9\u7167\u5206\u6790\u3002\u7f8e\u56fd\u6ccc\u5c3f\u5916\u79d1\u6742\u5fd7 2016\u5e749\u6708\uff1b\u7b2c196\uff083\uff09\u671f\uff1a\u7b2c678-684\u9875\u3002\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5014677\/.\n\n4 Shinder B et al. \u665a\u671f\u548c\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684\u624b\u672f\u6cbb\u7597\uff1a\u591a\u5b66\u79d1\u65b9\u6cd5\u3002 Frontiers in Oncology. 2017\u5e74\uff1b\u7b2c7\u671f\uff1a\u7b2c107\u9875\u3002\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449498\/#ffn sectitle.\n\n5 \u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff0c\u300a\u5b50\u5bab\u4f53\u764c\u7b80\u62a5\u300bCancer Today\uff0c2020\u5e74\u3002\nhttps:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/24-Corpus-uteri-fact-sheet.pdf.\n\n6 \u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff0cFacts & Figures 2020 pdf\uff1a\nhttps:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/cancer-facts-figures-2020.html\n\n7 Padala, S. A., Barsouk, A., Thandra, K. C., Saginala, K., Mohammed, A., Vakiti, A., Rawla, P., & Barsouk, A. (2020).\u80be\u7ec6\u80de\u764c\u6d41\u884c\u75c5\u5b66\u3002\u4e16\u754c\u80bf\u7624\u5b66\u6742\u5fd7\uff0c\u7b2c11\uff083\uff09\u671f\uff0c\u7b2c79-87\u9875\nhttps:\/\/doi.org\/10.14740\/wjon1279.\n\n8 \u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u7f51\u7ad9\uff0c\u8bbf\u95ee\u65e5\u671f\uff1a2021\u5e742\u67081\u65e5\uff1a\nhttps:\/\/www.cancer.org\/cancer\/endometrial-cancer\/detection-diagnosis-staging\/survival-rates.html.\n<\/p>\n","protected":false},"excerpt":{"rendered":"
\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u5df2\u786e\u8ba4\u53d7\u7406\u536b\u6750\u81ea\u4e3b\u7814\u53d1\u7684\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff08\u4ea7\u54c1\u540d\u79f0\uff1aLENVIMA\u00ae\/Kisplyx\u00ae\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u4ed1\u4f10\u66ff\u5c3c\u201d\uff09\u8054\u5408MSD\u7814\u53d1\u7684\u6297PD-1\u836f\u7269\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u5546\u54c1\u540d\uff1aKEYTRUDA\u00ae\uff09\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u548c\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\uff08EC\uff09\u7684\u5ba1\u8bc4\u7533\u8bf7\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"_links":{"self":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/4798"}],"collection":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/comments?post=4798"}],"version-history":[{"count":1,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/4798\/revisions"}],"predecessor-version":[{"id":4799,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/4798\/revisions\/4799"}],"wp:attachment":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/media?parent=4798"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/categories?post=4798"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/tags?post=4798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}久久人人97超碰超国产,天天摸夜夜添夜夜无码,久久精品人人槡人妻人人玩,97碰碰碰人妻无码视频