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[2.61\uff0c7.91]\uff09\u3002<\/p>\n<p>\u572818\u9879HRQoL\u548c\u75be\u75c5\u76f8\u5173\u75c7\u72b6\u8bc4\u5206\u4e2d\uff0c\u4e50\u536b\u739b+\u53ef\u745e\u8fbe\u7ec414\u9879\u8bc4\u5206\u7684TTD\u4e0e\u8212\u5c3c\u66ff\u5c3c\u7ec4\u76f8\u4f3c\uff0c\u751f\u7406\u673a\u80fd\u3001\u547c\u5438\u56f0\u96be\u3001\u98df\u6b32\u4e0b\u964d\u548cEQ-5D\u89c6\u89c9\u6a21\u62df\u91cf\u8868\u7684TTD\u8fdf\u4e8e\u8212\u5c3c\u66ff\u5c3c\u7ec4\u3002\u572818\u9879HRQoL\u548c\u75be\u75c5\u76f8\u5173\u75c7\u72b6\u8bc4\u5206\u4e2d\uff0c\u4e50\u536b\u739b+\u53ef\u745e\u8fbe\u7ec416\u9879\u8bc4\u5206\u7684TUDD\u8fdf\u4e8e\u8212\u5c3c\u66ff\u5c3c\u7ec4\uff0c\u8ba4\u77e5\u529f\u80fd\u548c\u7ecf\u6d4e\u56f0\u96be\u7684TUDD\u4e0e\u8212\u5c3c\u66ff\u5c3c\u7ec4\u76f8\u4f3c\u3002<\/p>\n<p><em>Motzer<\/em><em>\u535a\u58eb\u4e3aMSD\u548c\u536b\u6750\u63d0\u4f9b\u54a8\u8be2\u670d\u52a1\u3002<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u4e50\u536b\u739b<sup>\u00ae<\/sup>\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u80f6\u56ca<\/strong><\/p>\n<p>\u4e50\u536b\u739b\u662f\u7531\u536b\u6750\u53d1\u73b0\u5e76\u5f00\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u591a\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53VEGFR1\uff08FLT1\uff09\u3001VEGFR2\uff08KDR\uff09\u548cVEGFR3\uff08FLT4\uff09\u7684\u6fc0\u9176\u6d3b\u6027\u3002\u9664\u6b63\u5e38\u7ec6\u80de\u529f\u80fd\u5916\uff0c\u4e50\u536b\u739b\u8fd8\u53ef\u6291\u5236\u4e0e\u81f4\u75c5\u6027\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u751f\u957f\u548c\u764c\u75c7\u8fdb\u5c55\u76f8\u5173\u7684\u5176\u4ed6\u6fc0\u9176\uff0c\u5305\u62ec\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53FGFR1-4\u3001\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u03b1\uff08PDGFR\u03b1\uff09\u3001KIT\u548cRET\u3002\u5728\u540c\u7cfb\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u4e0e\u4efb\u4e00\u836f\u7269\u5355\u72ec\u7ed9\u836f\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\u53ef\u51cf\u5c11\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u589e\u52a0\u6d3b\u5316\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u4e0e\u4efb\u4e00\u836f\u7269\u5355\u72ec\u7ed9\u836f\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u548c\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u836f\u663e\u793a\u6297\u8840\u7ba1\u751f\u6210\u548c\u6297\u80bf\u7624\u6d3b\u6027\u589e\u52a0\uff0c\u8868\u73b0\u4e3a\u4f53\u5916\u4eba\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u3001\u7ba1\u5f62\u6210\u548cVEGF\u4fe1\u53f7\u51cf\u5c11\uff0c\u4ee5\u53ca\u4eba\u80be\u7ec6\u80de\u764c\u5c0f\u9f20\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u80bf\u7624\u4f53\u79ef\u51cf\u5c0f\u3002<\/p>\n<p>\u4e50\u536b\u739b\u5df2\u5728\u8d85\u8fc770\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u7528\u4e8e\u653e\u5c04\u6027\u7898\u96be\u6cbb\u6027\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u7684\u5355\u836f\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u4e50\u536b\u739b\u5df2\u5728\u8d85\u8fc770\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u65e5\u672c\u3001\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u5355\u836f\u6cbb\u7597\u3002\u5728\u8d85\u8fc760\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\uff0c\u4e50\u536b\u739b\u8fd8\u88ab\u6279\u51c6\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u836f\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u66fe\u63a5\u53d7\u8fc7\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u7684\u80be\u7ec6\u80de\u764c\u60a3\u8005\u3002\u5728\u6b27\u6d32\uff0c\u4e50\u536b\u739b\u4ee5\u5546\u54c1\u540dKisplyx<sup>\u00ae<\/sup>\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3002\u540c\u65f6\uff0c\u4e50\u536b\u739b\u4e5f\u5728\u8d85\u8fc710\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u548c\u6fb3\u5927\u5229\u4e9a\uff09\u83b7\u6279\u7528\u4e8e\u4e0e\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u6cbb\u7597\u5728\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3001\u4e0d\u9002\u5408\u6839\u6cbb\u6027\u624b\u672f\u6216\u653e\u7597\u7684\u975e\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002\u8be5\u9002\u5e94\u75c7\u7684\u6301\u7eed\u6279\u51c6\u53d6\u51b3\u4e8e\u5404\u9879\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002\u4e50\u536b\u739b\u5728\u65e5\u672c\u4e5f\u88ab\u6279\u51c6\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u80f8\u817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mg<\/strong><\/p>\n<p>\u53ef\u745e\u8fbe\u662f\u4e00\u79cd\u6297PD-1\u6cbb\u7597\u836f\u7269\uff0c\u901a\u8fc7\u63d0\u9ad8\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u5e2e\u52a9\u76d1\u6d4b\u548c\u6297\u51fb\u80bf\u7624\u7ec6\u80de\u7684\u80fd\u529b\u53d1\u6325\u4f5c\u7528\u3002\u53ef\u745e\u8fbe\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u963b\u65adPD-1\u4e0e\u5176\u914d\u4f53PD-L1\u548cPD-L2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6fc0\u6d3bT\u6dcb\u5df4\u7ec6\u80de\uff0c\u8fd9\u79cd\u6dcb\u5df4\u7ec6\u80de\u53ef\u80fd\u5bf9\u80bf\u7624\u7ec6\u80de\u548c\u5065\u5eb7\u7ec6\u80de\u5747\u6709\u4f5c\u7528\u3002<\/p>\n<p>MSD\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u884c\u4e1a\u5185\u89c4\u6a21\u6700\u5927\u7684\u514d\u75ab\u80bf\u7624\u5b66\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u3002\u76ee\u524d\u67091400\u591a\u9879\u5728\u591a\u79cd\u764c\u75c7\u548c\u6cbb\u7597\u73af\u5883\u4e2d\u7814\u7a76\u53ef\u745e\u8fbe\u7684\u8bd5\u9a8c\u3002\u53ef\u745e\u8fbe\u4e34\u5e8a\u9879\u76ee\u65e8\u5728\u4e86\u89e3\u53ef\u745e\u8fbe\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u53ef\u80fd\u9884\u6d4b\u60a3\u8005\u4ece\u53ef\u745e\u8fbe\u6cbb\u7597\u4e2d\u83b7\u76ca\u53ef\u80fd\u6027\u7684\u56e0\u7d20\uff0c\u5305\u62ec\u63a2\u7d22\u51e0\u79cd\u4e0d\u540c\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8eCLEAR\uff08\u7814\u7a76307\uff09\/KEYNOTE-581<\/strong><\/p>\n<p>CLEAR\/KEYNOTE-581\u8bd5\u9a8c\u662f\u4e00\u9879\u8bc4\u4ef7\u4e50\u536b\u739b\u8054\u5408\u53ef\u745e\u8fbe\u6216\u4f9d\u7ef4\u83ab\u53f8\u5bf9\u6bd4\u8212\u5c3c\u66ff\u5c3c\u7528\u4e8e\u665a\u671fRCC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u7684III\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6027\u8bd5\u9a8c\uff08ClinicalTrials.gov\uff0c<u>NCT02811861<\/u>\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u6839\u636eRECIST 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50\u5e0c\u671b\u4ece\u8fd9\u4e9b<em>Ricchi<\/em>\u4e2d\u53d1\u73b0\u5177\u6709\u65b0\u9776\u70b9\u3001\u65b0\u4f5c\u7528\u673a\u5236\u5e76\u6709\u671b\u6cbb\u6108\u764c\u75c7\u7684\u521b\u65b0\u836f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750<\/strong><\/p>\n<p>\u536b\u6750\u662f\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684\u7814\u53d1\u578b\u5236\u836f\u516c\u53f8\uff0c\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\uff0c\u5728\u5168\u7403\u7ea6\u670910,000\u540d\u5458\u5de5\u3002\u536b\u6750\u5c06\u4f01\u4e1a\u4f7f\u547d\u5b9a\u4e49\u4e3a\u201c\u5c06\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u201d\uff0c\u516c\u53f8\u5c06\u8fd9\u79cd\u4f7f\u547d\u79f0\u4e3a\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<em>hhc<\/em>\uff09\u7406\u5ff5\u3002\u536b\u6750\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u5b66\u548c\u795e\u7ecf\u75c5\u5b66\u7b49\u533b\u7597\u9700\u6c42\u9ad8\u5ea6\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u521b\u65b0\u4ea7\u54c1\uff0c\u52aa\u529b\u5b9e\u73b0\u516c\u53f8\u7684<em>hhc<\/em>\u7406\u5ff5\u3002\u672c\u7740<em>hhc<\/em>\u7684\u7cbe\u795e\uff0c\u536b\u6750\u4f1a\u8fdb\u4e00\u6b65\u5c65\u884c\u8fd9\u4e00\u627f\u8bfa\uff0c\u8fd0\u7528\u516c\u53f8\u62e5\u6709\u7684\u79d1\u5b66\u4e13\u4e1a\u77e5\u8bc6\u3001\u4e34\u5e8a\u80fd\u529b\u548c\u5bf9\u60a3\u8005\u7684\u4e86\u89e3\uff0c\u53d1\u73b0\u5e76\u5f00\u53d1\u521b\u65b0\u89e3\u51b3\u65b9\u6848\uff0c\u5e2e\u52a9\u89e3\u51b3\u793e\u4f1a\u6700\u68d8\u624b\u7684\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u9700\u6c42\uff0c\u5305\u62ec\u88ab\u5ffd\u89c6\u7684\u70ed\u5e26\u75c5\u548c\u53ef\u6301\u7eed\u53d1\u5c55\u76ee\u6807\u3002<\/p>\n<p>\u6709\u5173\u536b\u6750\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<u>www.eisai.com<\/u>\uff08\u9002\u7528\u4e8e\u5168\u7403\uff09\u3001<u>us.eisai.com<\/u>\uff08\u9002\u7528\u4e8e\u7f8e\u56fd\uff09\u6216<u>www.eisai.eu<\/u>\uff08\u9002\u7528\u4e8e\u6b27\u6d32\u3001\u4e2d\u4e1c\u3001\u975e\u6d32\uff09\uff0c\u4e5f\u53ef\u901a\u8fc7Twitter\uff08<u>\u7f8e\u56fd<\/u>\u548c<u>\u5168\u7403<\/u>\uff09\u548c<u>LinkedIn<\/u>\uff08\u9002\u7528\u4e8e\u7f8e\u56fd\uff09\u4e0e\u6211\u4eec\u8054\u7cfb\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><sup>1 <\/sup>\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff0c\u300a\u80be\u764c\u7b80\u62a5\u300b\uff0cCancer Today\uff0c2020\u5e74\u3002<u>https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/29-Kidney-fact-sheet.pdf<\/u> .<\/p>\n<p><sup>2 <\/sup>\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff0c\u300a\u65e5\u672c\u7b80\u62a5\u300b\uff0cCancer Today\uff0c2020\u5e74\u3002<u>https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/392-japan-fact-sheets.pdf <\/u>.<\/p>\n<p><sup>3 <\/sup>\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff0c\u300a\u6709\u5173\u80be\u764c\u7684\u5173\u952e\u7edf\u8ba1\u6570\u636e\u300b\uff0c<u>https:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-statistics.html <\/u>.<\/p>\n<p><sup>4 <\/sup>Thomas A. Z. et al. \u8f6c\u79fb\u7624\u5207\u9664\u672f\u5728\u80be\u7ec6\u80de\u764c\u4f34\u8089\u7624\u6837\u5206\u5316\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\uff1a\u5339\u914d\u5bf9\u7167\u5206\u6790\u3002\u300a\u7f8e\u56fd\u6ccc\u5c3f\u5916\u79d1\u6742\u5fd7\u300b\uff0c2016\u5e749\u6708\uff1b\u7b2c196\uff083\uff09\u671f\uff1a\u7b2c678-684\u9875\u3002<u>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5014677\/pdf\/nihms773463.pdf <\/u>.<\/p>\n<p><sup>5 <\/sup>Shinder B et al. \u665a\u671f\u548c\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684\u5916\u79d1\u6cbb\u7597\uff1a\u591a\u5b66\u79d1\u65b9\u6cd5 <em>Frontiers in Oncology.<\/em> 2017; 7: 107.<u>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449498\/#__ffn_sectitle <\/u>.<\/p>\n<p><sup>6 <\/sup>Padala, S. A., Barsouk, A., Thandra, K. C., Saginala, K., Mohammed, A., Vakiti, A., Rawla, P., &amp; Barsouk, A. (2020).\u300a\u80be\u7ec6\u80de\u764c\u6d41\u884c\u75c5\u5b66\u300b\uff0c\u4e16\u754c\u80bf\u7624\u5b66\u6742\u5fd7\uff0c\u7b2c11\uff083\uff09\u671f\uff0c\u7b2c79-87\u9875<u>https:\/\/doi.org\/10.14740\/wjon1279<\/u> .<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e1c\u4eac\u548c\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u601d\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u8054\u5408MSD\u8fd1\u65e5\u5ba3\u5e03\u4e86\u5173\u952e\u6027III\u671fCLEAR\u8bd5\u9a8c\uff08\u7814\u7a76307\uff09\/KEYNOTE-581\u8bd5\u9a8c\u6700\u65b0\u7814\u7a76\u6570\u636e\uff0c\u8be5\u8bd5\u9a8c\u5bf9\u4e50\u536b\u739b\uff08\u536b\u6750\u7814\u53d1\u7684\u53e3\u670d\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\uff09\u8054\u5408\u53ef\u745e\u8fbe\uff08MSD\u5f00\u53d1\u7684\u6297PD-1\u7597\u6cd5\uff09\u4ee5\u53ca\u4e50\u536b\u739b\u8054\u5408\u4f9d\u7ef4\u83ab\u53f8\u5bf9\u6bd4\u8212\u5c3c\u66ff\u5c3c\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u8fdb\u884c\u4e86\u7814\u7a76\u548c\u8bc4\u4ef7\u3002\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\uff08\u6458\u8981\u7f16\u53f74502\uff09\u7684\u53e3\u5934\u6458\u8981\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86\u57fa\u4e8e\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\u8bc4\u4ef7\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\uff08HRQoL\uff09\u7684\u65b0\u5206\u6790\u7ed3\u679c\u3002CLEAR\/KEYTNOTE-581\u7684\u6570\u636e\u6700\u521d\u57282021\u5e74\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u764c\u75c7\u7814\u8ba8\u4f1a\uff08ASCO GU\uff09\u4e0a\u516c\u5e03\uff0c\u5e76\u53d1\u8868\u4e8e\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff0c\u8be5\u8bd5\u9a8c\u7684\u6570\u636e\u76ee\u524d\u6b63\u5728\u63a5\u53d7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u5ba1\u67e5\u3002<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"_links":{"self":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/5450"}],"collection":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/comments?post=5450"}],"version-history":[{"count":4,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/5450\/revisions"}],"predecessor-version":[{"id":5495,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/5450\/revisions\/5495"}],"wp:attachment":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/media?parent=5450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/categories?post=5450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/tags?post=5450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<a href="http://www.9-design.net/">久久人人97超碰超国产,天天摸夜夜添夜夜无码,久久精品人人槡人妻人人玩,97碰碰碰人妻无码视频</a>
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