{"id":5538,"date":"2021-06-23T15:13:01","date_gmt":"2021-06-23T07:13:01","guid":{"rendered":"https:\/\/www.9-design.net\/?p=5538"},"modified":"2021-07-13T15:18:20","modified_gmt":"2021-07-13T07:18:20","slug":"%e6%97%a5%e6%9c%ac%e6%89%b9%e5%87%86%e6%8a%97%e7%99%8c%e8%8d%aftazverik200-mg%e7%89%87%e5%89%82%ef%bc%88%e6%b0%a2%e6%ba%b4%e9%85%b8%e6%b3%b0%e6%b3%bd%e5%8f%b8%e4%bb%96%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.9-design.net\/2021\/06\/23\/%e6%97%a5%e6%9c%ac%e6%89%b9%e5%87%86%e6%8a%97%e7%99%8c%e8%8d%aftazverik200-mg%e7%89%87%e5%89%82%ef%bc%88%e6%b0%a2%e6%ba%b4%e9%85%b8%e6%b3%b0%e6%b3%bd%e5%8f%b8%e4%bb%96%ef%bc%89\/","title":{"rendered":"\u65e5\u672c\u6279\u51c6\u6297\u764c\u836f\u201cTAZVERIK\u00ae200 mg\u7247\u5242\u201d\uff08\u6c22\u6eb4\u9178\u6cf0\u6cfd\u53f8\u4ed6\uff09\u7528\u4e8e\u6cbb\u7597EZH2\u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624"},"content":{"rendered":"<p style=\"text-align: left\">\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5df2\u5728\u65e5\u672c\u83b7\u5f97EZH2\u6291\u5236\u5242\u201cTazverik<sup>\u00ae<\/sup>200 mg\u7247\u5242\u201d\uff08\u6c22\u6eb4\u9178\u6cf0\u6cfd\u53f8\u4ed6\uff09\u7684\u751f\u4ea7\u548c\u4e0a\u5e02\u8bb8\u53ef\uff0c\u7528\u4e8e\u6cbb\u7597EZH2\u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08\u4ec5\u5728\u6807\u51c6\u6cbb\u7597\u4e0d\u9002\u7528\u65f6\u4f7f\u7528\uff09\u3002<\/p>\n<p style=\"text-align: left\">\u672c\u6b21\u83b7\u6279\u57fa\u4e8e\u536b\u6750\u5728\u65e5\u672c\u5f00\u5c55\u7684\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6027\u3001\u5355\u81c2II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u7814\u7a76206\uff09<sup>1<\/sup>\u548cEpizyme, 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91.5\uff09\u3002\u8be5\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08\u53d1\u751f\u7387\u226525%\uff09\u4e3a\u5473\u89c9\u969c\u788d\uff0852.9%\uff09\u3001\u9f3b\u54bd\u708e\uff0835.3%\uff09\u3001\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\uff0829.4%\uff09\u548c\u8840\u808c\u9178\u78f7\u9178\u6fc0\u9176\u5347\u9ad8\uff0829.4%\uff09\u3002\u536b\u6750\u5c06\u6839\u636eMHLW\u89c4\u5b9a\u7684\u6279\u51c6\u6761\u4ef6\uff0c\u5bf9\u6240\u6709\u63a5\u53d7\u201cTazverik\u201d\u6cbb\u7597\u7684\u60a3\u8005\u5f00\u5c55\u4e00\u9879\u4e0a\u5e02\u540e\u7279\u6b8a\u4f7f\u7528\u7ed3\u679c\u8c03\u67e5\uff08\u6240\u6709\u75c5\u4f8b\u76d1\u6d4b\uff09\uff0c\u76f4\u5230\u8fbe\u5230\u9884\u5b9a\u7684\u60a3\u8005\u6570\u91cf\u3002<\/p>\n<p style=\"text-align: left\">\u201cTazverik\u201d\u662f\u8868\u89c2\u9057\u4f20\u9176EZH2\u7684\u4e00\u79cd\u65b0\u578b\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u901a\u8fc7Epizyme\u7684\u4e13\u5229\u4ea7\u54c1\u5e73\u53f0\u521b\u5efa\u3002\u201cTazverik\u201d\u662f\u4e00\u5927\u7c7b\u8868\u89c2\u9057\u4f20\u76f8\u5173\u86cb\u767d\u4e2d\u7684\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176\u4e4b\u4e00\uff0c\u901a\u8fc7\u7279\u5f02\u6027\u9776\u5411\u4fc3\u8fdb\u764c\u75c7\u8fdb\u5c55\u7684EZH2\uff0c\u8c03\u8282\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u3001\u6291\u5236\u764c\u7ec6\u80de\u7684\u751f\u957f<sup>3<\/sup>\u3002\u536b\u6750\u8d1f\u8d23\u8be5\u836f\u7269\u5728\u65e5\u672c\u7684\u5f00\u53d1\u548c\u9500\u552e\uff0c\u800cEpizyme\u8d1f\u8d23\u65e5\u672c\u4ee5\u5916\u7684\u6240\u6709\u5730\u533a\u3002\u5728\u7f8e\u56fd\uff0c\u201cTazverik\u201d\u4e8e2020\u5e741\u6708\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u4e0a\u76ae\u6837\u8089\u7624\uff0c2020\u5e746\u6708\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08\u7f16\u8005\u6ce81\uff09\u3002<\/p>\n<p style=\"text-align: left\">\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u662f\u4e00\u79cd\u4f4e\u7ea7\u522bB\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u5360\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u768410-20%\u3002\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u901a\u5e38\u751f\u957f\u7f13\u6162\uff0c\u800c\u4e14\u5bf9\u5316\u7597\u654f\u611f\u3002\u7136\u800c\uff0c\u56e0\u4e3a\u8be5\u75be\u75c5\u53cd\u590d\u590d\u53d1\uff0c\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u4ecd\u96be\u4ee5\u6cbb\u6108\uff0c\u9700\u8981\u7814\u53d1\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u3002\u636e\u62a5\u9053\uff0c7%\u81f327%\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u4f34\u6709EZH2\u57fa\u56e0\u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8<sup>4,5<\/sup>\uff0c\u5728\u65e5\u672c\u7ea6\u6709600\u81f32400\u540d\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u53d1\u751fEZH2\u7a81\u53d8\u3002Roche Diagnostics K.K.\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff09\u7684EZH2\u57fa\u56e0\u7a81\u53d8\u4f34\u968f\u8bca\u65ad\u68c0\u6d4b\u201ccobas<sup>\u00ae<\/sup>EZH2\u7a81\u53d8\u68c0\u6d4b\u201d\u4e8e2021\u5e745\u6708\u83b7\u5f97\u6279\u51c6\u3002<\/p>\n<p style=\"text-align: left\">\u536b\u6750\u65e8\u5728\u63d0\u4f9b\u201cTazverik\u201d\u4f5c\u4e3aEZH2\u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u65b0\u6cbb\u7597\u9009\u62e9\uff0c\u6301\u7eed\u6ee1\u8db3\u764c\u75c7\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u548c\u533b\u52a1\u4eba\u5458\u7684\u591a\u6837\u5316\u9700\u6c42\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\"><strong>\u5a92\u4f53\u54a8\u8be2\uff1a<\/strong><\/p>\n<p style=\"text-align: left\">\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/p>\n<p style=\"text-align: left\">\u516c\u5171\u5173\u7cfb\u90e8<\/p>\n<p style=\"text-align: left\">+81-(0)3-3817-5120<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\"><strong>[<\/strong><strong>\u7f16\u8005\u6ce8<\/strong><strong>]<\/strong><\/p>\n<p style=\"text-align: left\"><strong>1.<\/strong><strong>\u5173\u4e8e<\/strong><strong>\u201c<\/strong><strong>Tazverik 200 mg<\/strong><strong>\u7247\u5242<\/strong><strong>\u201d<\/strong><strong>\uff08\u6c22\u6eb4\u9178\u6cf0\u6cfd\u53f8\u4ed6\uff0c\u7814\u53d1\u4ee3\u7801\uff1a<\/strong><strong>E7438<\/strong><strong>\uff0c<\/strong><strong>Epizyme, Inc.<\/strong><strong>\u7684\u7814\u53d1\u4ee3\u7801\uff1a<\/strong><strong>EPZ-6438<\/strong><strong>\uff09<\/strong><\/p>\n<p style=\"text-align: left\">\u201cTazverik\u201d\u662f\u4e00\u79cd\u9776\u5411EZH2\u7684\u65b0\u578b\u53e3\u670d\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3002\u6839\u636e\u53cc\u65b92011\u5e743\u6708\u8fbe\u6210\u7684\u9488\u5bf9EZH2\u7684\u7814\u53d1\u548c\u9500\u552e\u5408\u4f5c\u534f\u8bae\uff0c\u536b\u6750\u548cEpizyme\u5229\u7528Epizyme\u7684\u4e13\u5229\u4ea7\u54c1\u5e73\u53f0\u8fdb\u884c\u4e86\u8054\u5408\u7814\u53d1\u3002\u8be5\u836f\u7269\u9009\u62e9\u6027\u5730\u6291\u5236EZH2\uff0cEZH2\u4e0eS-\u817a\u82f7\u7532\u786b\u6c28\u9178\uff08\u7532\u57fa\u4f9b\u4f53\uff09\u7ade\u4e89\uff0c\u4ece\u800c\u6291\u5236H3K27\u7684\u7532\u57fa\u5316\u3002\u7531\u4e8e2015\u5e743\u6708\u4e24\u5bb6\u516c\u53f8\u7684\u5408\u4f5c\u534f\u8bae\u53d1\u751f\u53d8\u66f4\uff0c\u536b\u6750\u8d1f\u8d23\u8be5\u836f\u7269\u5728\u65e5\u672c\u7684\u5f00\u53d1\u548c\u9500\u552e\uff0c\u800cEpizyme\u8d1f\u8d23\u65e5\u672c\u4ee5\u5916\u7684\u6240\u6709\u5730\u533a\u3002<\/p>\n<p style=\"text-align: left\">\u5728\u65e5\u672c\u5c90\u961c\u53bf\u7684\u5ddd\u5c9b\u5de5\u4e1a\u56ed\uff0c\u4e5f\u5c31\u662f\u672c\u54c1\u5728\u65e5\u672c\u7684\u751f\u4ea7\u5730\u70b9\uff0c\u536b\u6750\u5df2\u6210\u529f\u5f00\u53d1\u51fa\u521b\u65b0\u7684\u5236\u836f\u751f\u4ea7\u6280\u672f\uff0c\u5373\u6240\u8c13\u7684\u201c\u6301\u7eed\u751f\u4ea7\u201d\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u4e8e\u5b9e\u9645\u751f\u4ea7\u3002\u6301\u7eed\u751f\u4ea7\u901a\u8fc7\u96c6\u6210\u5236\u9020\u81ea\u52a8\u5316\u548c\u5b9e\u65f6\u8d28\u91cf\u76d1\u6d4b\u6280\u672f\uff0c\u6709\u52a9\u4e8e\u836f\u54c1\u7684\u8d28\u91cf\u6539\u8fdb\u548c\u7a33\u5b9a\u4f9b\u5e94\u3002\u6b64\u5916\uff0c\u8fde\u7eed\u751f\u4ea7\u4f5c\u4e3a\u4e00\u79cd\u65b0\u7684\u836f\u54c1\u751f\u4ea7\u65b9\u6cd5\uff0c\u80fd\u591f\u63d0\u9ad8\u6548\u7387\u3001\u8282\u7701\u7a7a\u95f4\u548c\u80fd\u6e90\uff0c\u540c\u65f6\u51cf\u5c11\u73af\u5883\u8d1f\u8377\uff0c\u662f\u4e00\u9879\u5907\u53d7\u5173\u6ce8\u7684\u6280\u672f\u3002\u536b\u6750\u662f\u6700\u65e9\u91c7\u7528\u8fde\u7eed\u751f\u4ea7\u7cfb\u7edf\uff08CTS-MiGRA\uff09\u7684\u516c\u53f8\u4e4b\u4e00\uff0c\u5e76\u5c06\u8be5\u6280\u672f\u5e94\u7528\u4e8e\u672c\u54c1\u7684\u751f\u4ea7\u3002<\/p>\n<p style=\"text-align: left\">\u672c\u54c1\u4e8e2020\u5e741\u6708\u5728\u7f8e\u56fd\u83b7\u5f97\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u201c\u4e0d\u9002\u5408\u63a5\u53d7\u6839\u6cbb\u6027\u5207\u9664\u7684\u8f6c\u79fb\u6027\u6216\u5c40\u90e8\u665a\u671f\u4e0a\u76ae\u6837\u8089\u7624\u7684\u6210\u4eba\u548c\u226516\u5c81\u7684\u513f\u7ae5\u60a3\u8005\u201d\u3002\u6b64\u5916\uff0c\u540c\u5e746\u6708\uff0c\u672c\u54c1\u83b7\u5f97\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u201c\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c112\u79cd\u6cbb\u7597\u65b9\u6848\u4e14EZH2\u7a81\u53d8\u9633\u6027\uff08\u7ecfFDA\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\uff09\u7684\u6210\u4eba\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u201d\uff0c\u4ee5\u53ca\u201c\u6ca1\u6709\u4ee4\u4eba\u6ee1\u610f\u7684\u66ff\u4ee3\u6cbb\u7597\u9009\u62e9\u7684\u6210\u4eba\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u201d\u3002<\/p>\n<p style=\"text-align: left\"><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: left\"><strong>2.<\/strong><strong>\u5173\u4e8e\u8868\u89c2\u9057\u4f20\u5b66<\/strong><\/p>\n<p style=\"text-align: left\">\u8868\u89c2\u9057\u4f20\u5b66\u662f\u7814\u7a76\u57fa\u56e0\u529f\u80fd\u83b7\u5f97\u6027\u6fc0\u6d3b\/\u5931\u6d3b\u673a\u5236\u7684\u79d1\u5b66\u5206\u652f\uff0c\u7814\u7a76\u5728DNA\u78b1\u57fa\u5e8f\u5217\u4e0d\u53d1\u751f\u6539\u53d8\u7684\u60c5\u51b5\u4e0b\uff0c\u57fa\u56e0\u529f\u80fd\u5982\u4f55\u901a\u8fc7\u7ec6\u80de\u5206\u88c2\u8fdb\u884c\u9057\u4f20\u3002\u5bfc\u81f4\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u7684\u4fee\u9970\u5b9e\u4f8b\u5305\u62ecDNA\u7684\u7532\u57fa\u5316\u548c\u7ec4\u86cb\u767d\u7684\u4fee\u9970\uff08\u7532\u57fa\u5316\u3001\u4e59\u9170\u5316\u3001\u78f7\u9178\u5316\u7b49\uff09\u3002<\/p>\n<p style=\"text-align: left\"><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: left\"><strong>3.<\/strong><strong>\u5173\u4e8e<\/strong><strong>EZH2<\/strong><\/p>\n<p style=\"text-align: left\">EZH2\u662f\u4e00\u5927\u7c7b\u8868\u89c2\u9057\u4f20\u76f8\u5173\u86cb\u767d\u4e2d\u7684\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176\u4e4b\u4e00\uff0c\u7279\u5f02\u6027\u50ac\u5316\u7ec4\u86cb\u767dH3\u5728\u8d56\u6c28\u917827\uff08H3K27\uff09\u7684\u7532\u57fa\u5316\uff0c\u4ece\u800c\u63a7\u5236\u5404\u79cd\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u7814\u7a76\u8868\u660e\uff0c\u7531EZH2\u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8\u3001\u8fc7\u8868\u8fbe\u6216EZH2\u6291\u5236\u56e0\u5b50\u7684\u529f\u80fd\u969c\u788d\u5f15\u8d77\u7684H3K27\u7532\u57fa\u5316\u589e\u52a0\u5728\u81f4\u764c\u8fc7\u7a0b\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\"><sup>1<\/sup> Shinya Rai\uff0cet al. Tazemetostat\u6cbb\u7597\u65e5\u672c\u590d\u53d1\u6216\u96be\u6cbb\u6027EZH2\u7a81\u53d8\u9633\u6027\u7684B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684II\u671f\u7814\u7a76\u30022021\u5e74AACR\u4f1a\u8bae\uff0cCT176.<\/p>\n<p style=\"text-align: left\"><sup>2<\/sup> Franck Morschhauser\uff0cet al. Tazemetostat\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\uff1a\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001II\u671f\u8bd5\u9a8c\u3002\u300a\u67f3\u53f6\u5200\u80bf\u7624\u5b66\u300b\uff0c2020\u5e7411\u6708\uff1b21(11):1433-1442\u3002<\/p>\n<p style=\"text-align: left\"><sup>3<\/sup> Sarah K. Knutson, Satoshi Kawano, Yukinori Minoshima, et al. EPZ-6438\u9009\u62e9\u6027\u6291\u5236EZH2\u53ef\u5bfc\u81f4\u5bf9EZH2\u7a81\u53d8\u578b\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u5f3a\u6548\u6297\u80bf\u7624\u6d3b\u6027\u3002<em>\u300a\u5206\u5b50\u764c\u75c7\u6cbb\u7597\u5b66\u300b\uff0c<\/em>2014\u5e744\u6708\uff1b13(4):842-854\u3002<\/p>\n<p style=\"text-align: left\"><sup>4<\/sup> Csaba B\u00f6d\u00f6r\uff0cet al. EZH2\u7a81\u53d8\u9891\u7e41\uff0c\u4ee3\u8868\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u65e9\u671f\u4e8b\u4ef6\u3002\u300a\u8840\u6db2\u5b66\u300b\uff0c2013\u5e7410\u6708\uff1b122(18), 3165-3168\u3002<\/p>\n<p style=\"text-align: left\"><sup>5<\/sup> Ryan D. Morin, et al. \u751f\u53d1\u4e2d\u5fc3\u8d77\u6e90\u7684\u6ee4\u6ce1\u6027\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4f53\u7ec6\u80deEZH2\uff08Y641\uff09\u7a81\u53d8\u3002\u300a\u81ea\u7136\u9057\u4f20\u5b66\u300b\uff0c2010\u5e742\u6708\uff1b42(2): 181-185\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5df2\u5728\u65e5\u672c\u83b7\u5f97EZH2\u6291\u5236\u5242\u201cTazverik\u00ae200 mg\u7247\u5242\u201d\uff08\u6c22\u6eb4\u9178\u6cf0\u6cfd\u53f8\u4ed6\uff09\u7684\u751f\u4ea7\u548c\u4e0a\u5e02\u8bb8\u53ef\uff0c\u7528\u4e8e\u6cbb\u7597EZH2\u57fa\u56e0\u7a81\u53d8\u9633\u6027\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08\u4ec5\u5728\u6807\u51c6\u6cbb\u7597\u4e0d\u9002\u7528\u65f6\u4f7f\u7528\uff09\u3002<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"_links":{"self":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/5538"}],"collection":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/comments?post=5538"}],"version-history":[{"count":4,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/5538\/revisions"}],"predecessor-version":[{"id":5543,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/posts\/5538\/revisions\/5543"}],"wp:attachment":[{"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/media?parent=5538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/categories?post=5538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.9-design.net\/wp-json\/wp\/v2\/tags?post=5538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<a href="http://www.9-design.net/">久久人人97超碰超国产,天天摸夜夜添夜夜无码,久久精品人人槡人妻人人玩,97碰碰碰人妻无码视频</a>
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